Measurement of Mucosal Conductivity by MII Is a Potential Marker of Mucosal Integrity Restored in Infants on Acid-suppression Therapy

Clara Loots, Michiel van Wijk, Marije Smits, Tobias Wenzl, Marc Benninga, Taher Omari

    Research output: Contribution to journalArticlepeer-review

    32 Citations (Scopus)

    Abstract

    Esophageal multichannel intraluminal impedance (MII) allows measurement of the conductivity of adjacent contents. During esophageal rest, raw impedance levels may represent mucosal integrity. We assessed the influence of proton pump inhibitors (PPIs) on presumed mucosal integrity by reanalyzing raw MII levels of 21 pH-MII tracings from infants with gastroesophageal reflux (GER) disease before and after esomeprazole treatment. Median (interquartile range) esophageal MII increased during treatment, 938 (652-1304) versus 1885 (1360-2183) Ohm, P < 0.0001. Patients with lower MII levels demonstrated a larger increase on therapy: Spearman r = 0.28, P = 0.014. No correlation with standard GER parameters was observed. In conclusion, PPI therapy increases MII levels in infants with symptomatic GER disease.

    Original languageEnglish
    Pages (from-to)120-123
    Number of pages4
    JournalJournal of Pediatric Gastroenterology and Nutrition
    Volume53
    Issue number1
    DOIs
    Publication statusPublished - Jul 2011

    Keywords

    • children
    • dilated intracellular spaces
    • esomeprazole
    • impedance
    • infants
    • mucosal integrity
    • pH impedance
    • proton pump inhibitor
    • reflux
    • reflux disease treatment

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