Mechanisms of Spinal Cord Plasticity in Rodent Models of Acute and Post-Colitis Visceral Hypersensitivity

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Inflammation of the colon is well-established as an initiating factor in the development of chronic visceral pain. Colitis induces sensitisation at peripheral and central sites of the sensory afferent pathways that relay nociceptive signals into the brain. Sensitisation within the spinal cord is an important mechanism maintaining chronic visceral pain beyond colitis resolution and facilitates the development of cross-organ sensitization. This minireview summarises what is currently known from animal acute and post-colitis models on spinal sensitisation and the plasticity involved. These mechanisms have relevance to human inflammatory and functional bowel disorders such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). These prevalent conditions afflict millions of people globally and yet adequate treatments for the chronic visceral pain associated with these disorders are lacking.

Original languageEnglish
Title of host publicationVisceral Pain
EditorsStuart M. Brierley, Nick J. Spencer
Place of PublicationCham, Switzerland
PublisherSpringer International Publishing
Number of pages14
ISBN (Electronic)9783031257025
ISBN (Print)9783031257018
Publication statusPublished - 2023


  • Colitis
  • Colon
  • Dorsal horn and chronic visceral pain
  • Nociception
  • Rectum
  • Spinal cord
  • Visceral afferent pathways
  • Visceral pain


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