Mechanosensory Transduction

David Grundy, Simon Brookes

    Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

    1 Citation (Scopus)

    Abstract

    Visceral afferent fibers convey a vast amount of sensory information to the brain stem and spinal cord. Two major mechanisms underlie signal transduction evoked by local distortion of nerve endings. The first is 'indirect,' or 'chemical,' transduction whereby another cell type (e.g., the enterochromaffin cell) is activated by the stimulus and then releases a transmitter such as 5-hydroxytryptamine onto the sensory axon, causing it to fire. The second is direct mechanosensitivity, which arises because of the presence of mechanically sensitive ion channels in the nerve terminal membrane. In addition to transduction mechanisms, substantial modulation of the excitability of peripheral sensory endings occurs during tissue injury and inflammation.
    Original languageEnglish
    Title of host publicationEncyclopedia of Neuroscience
    PublisherElsevier
    Pages697-702
    Number of pages6
    ISBN (Print)9780080450469
    DOIs
    Publication statusPublished - 2009

    Keywords

    • 5-HT
    • ATP
    • Pelvic afferent
    • Sensory transduction
    • Spinal afferent
    • Vagal afferent

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