Mediastinal parathyroid carcinoma presenting with severe skeletal manifestations

Tuck Yong, Jordan Li

    Research output: Contribution to journalArticlepeer-review

    10 Citations (Scopus)


    Parathyroid carcinoma is a rare malignancy, accounting for about 1% of primary hyperparathyroidism. We report the case of a 23-year-old man who presented with poorly united mid-shaft fracture of the left femur with severe hypercalcaemia in the setting of 99 mTc sestamibi-avid lesions in the mediastinal and thoracic vertebrae. The patient underwent surgery, and histopathology revealed a low-grade parathyroid carcinoma. After surgery, the patient developed severe hungry bone syndrome requiring intensive calcium, magnesium and active vitamin D supplementation. A review of the literature was undertaken with regards to mediastinal parathyroid carcinoma, management of refractory hypercalcaemia in this setting and hungry bone syndrome.

    Original languageEnglish
    Pages (from-to)591-594
    Number of pages4
    JournalJournal of Bone and Mineral Metabolism
    Issue number5
    Publication statusPublished - Sept 2010


    • Brown tumour
    • Hypercalcaemia
    • Hyperparathyroidism
    • Parathyroid carcinoma


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