TY - JOUR
T1 - Medical progress: Melioidosis
AU - Wiersinga, Willem
AU - Currie, Bart
AU - Peacock, Sharon
PY - 2012/9/13
Y1 - 2012/9/13
N2 - MELIOIDOSIS, CAUSED BY THE ENVIRONMENTAL GRAM-NEGATIVE BACILlus Burkholderia pseudomallei, is classically characterized by pneumonia and multiple abscesses, with a mortality rate of up to 40%. It is an important cause of community-acquired sepsis in Southeast Asia and northern Australia. Its known global distribution is expanding, a reflection of improvements in diagnostic microbiology and increasing numbers of cases in travelers and returning military personnel (Fig. 1).1,2 A locally acquired case of melioidosis was recently described in the United States.3 B. pseudomallei has been classified by the Centers for Disease Control and Prevention as a category B bioterrorism agent, resulting in increased research and understanding of melioidosis. This review considers recent developments in pathogenesis, diagnostics, and treatment.
AB - MELIOIDOSIS, CAUSED BY THE ENVIRONMENTAL GRAM-NEGATIVE BACILlus Burkholderia pseudomallei, is classically characterized by pneumonia and multiple abscesses, with a mortality rate of up to 40%. It is an important cause of community-acquired sepsis in Southeast Asia and northern Australia. Its known global distribution is expanding, a reflection of improvements in diagnostic microbiology and increasing numbers of cases in travelers and returning military personnel (Fig. 1).1,2 A locally acquired case of melioidosis was recently described in the United States.3 B. pseudomallei has been classified by the Centers for Disease Control and Prevention as a category B bioterrorism agent, resulting in increased research and understanding of melioidosis. This review considers recent developments in pathogenesis, diagnostics, and treatment.
UR - http://www.scopus.com/inward/record.url?scp=84866067768&partnerID=8YFLogxK
U2 - 10.1056/NEJMra1204699
DO - 10.1056/NEJMra1204699
M3 - Review article
SN - 0028-4793
VL - 367
SP - 1035
EP - 1044
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 11
ER -