Older adults, particularly those >80 years, are the largest medication consumer group worldwide. Despite this, they remain largely excluded from participating in pre- and postmarketing clinical trials [1-6]. This is concerning as several studies have reported a significant increase in medication use in the older population, particularly over the last 20 years. Statins, angiotensin converting enzyme inhibitors, antiplatelet drugs, non-steroidal anti-inflammatory drugs, anticholinergic drugs, and proton pump inhibitors primarily account for the increased use [7-10]. Notably, safety issues with some of these drug classes have recently been raised although their extent might vary across different age groups [11-25].
- clinical trials
- old age