Melioidosis and the kidney

Zulfikar Jabbar, Bart Currie

    Research output: Contribution to journalReview articlepeer-review

    15 Citations (Scopus)


    Melioidosis, caused by the saprophytic soil and freshwater Gram-negative aerobic bacillus Burkholderia pseudomallei, is classically characterized by pneumonia, sometimes with multiple organ abscesses, usually in patients with defined risk factors and with a mortality rate of up to 40%. It is a major cause of community-Acquired sepsis in Southeast Asia and tropical northern Australia with an expanding global geographical distribution. It is increasingly recognized as an opportunistic infectious disease of importance to physicians, who may need to suspect it in at-risk patients that may come from or visit endemic areas, and could be fatal if treated late or inappropriately. Mortality could be prevented by early institution of specific antimicrobial therapy. Epidemiology, clinical features, overall management, and aspects of melioidosis particularly relevant to kidney disease and immunosuppression are discussed in this review. This in-depth review on melioidosis may stimulate attention for Asian countries on this easy to be neglected infectious disease. The importance also relies on the fact that mortality can be prevented by early institution of specific antimicrobial therapy.

    Original languageEnglish
    Pages (from-to)169-175
    Number of pages7
    Issue number3
    Publication statusPublished - Mar 2013


    • bioterrorism
    • Burkholderia pseudomallei
    • chronic kidney disease
    • immune suppression
    • melioidosis


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