Membrane topology of the metal-tetracycline/H+ antiporter TetA(K) from Staphylococcus aureus

Samantha L. Ginn, Melissa H. Brown, Ronald A. Skurray

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)


A series of fusions to the reporter proteins alkaline phosphatase and β-galactosidase have been constructed in the predicted periplasmic and cytoplasmic loops of TetA(K), a protein responsible for efflux-mediated tetracycline resistance in Staphylococcus aureus. The results support a topological model of 14 transmembrane segments for TetA(K).

Original languageEnglish
Pages (from-to)3786-3789
Number of pages4
JournalJournal of Bacteriology
Issue number11
Publication statusPublished - 1 Jan 1997
Externally publishedYes


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