Membrane topology of the metal-tetracycline/H+ antiporter TetA(K) from Staphylococcus aureus

Samantha L. Ginn; Melissa H. Brown; Ronald A. Skurray

doi:10.1128/jb.179.11.3786-3789.1997

Membrane topology of the metal-tetracycline/H⁺ antiporter TetA(K) from Staphylococcus aureus

Samantha L. Ginn
, Melissa H. Brown
, Ronald A. Skurray

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

Abstract

A series of fusions to the reporter proteins alkaline phosphatase and β-galactosidase have been constructed in the predicted periplasmic and cytoplasmic loops of TetA(K), a protein responsible for efflux-mediated tetracycline resistance in Staphylococcus aureus. The results support a topological model of 14 transmembrane segments for TetA(K).

Original language	English
Pages (from-to)	3786-3789
Number of pages	4
Journal	Journal of Bacteriology
Volume	179
Issue number	11
DOIs	https://doi.org/10.1128/jb.179.11.3786-3789.1997
Publication status	Published - 1 Jan 1997
Externally published	Yes

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title = "Membrane topology of the metal-tetracycline/H+ antiporter TetA(K) from Staphylococcus aureus",

abstract = "A series of fusions to the reporter proteins alkaline phosphatase and β-galactosidase have been constructed in the predicted periplasmic and cytoplasmic loops of TetA(K), a protein responsible for efflux-mediated tetracycline resistance in Staphylococcus aureus. The results support a topological model of 14 transmembrane segments for TetA(K).",

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AU - Brown, Melissa H.

AU - Skurray, Ronald A.

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Y1 - 1997/1/1

N2 - A series of fusions to the reporter proteins alkaline phosphatase and β-galactosidase have been constructed in the predicted periplasmic and cytoplasmic loops of TetA(K), a protein responsible for efflux-mediated tetracycline resistance in Staphylococcus aureus. The results support a topological model of 14 transmembrane segments for TetA(K).

AB - A series of fusions to the reporter proteins alkaline phosphatase and β-galactosidase have been constructed in the predicted periplasmic and cytoplasmic loops of TetA(K), a protein responsible for efflux-mediated tetracycline resistance in Staphylococcus aureus. The results support a topological model of 14 transmembrane segments for TetA(K).

UR - https://www.scopus.com/pages/publications/0030998934

U2 - 10.1128/jb.179.11.3786-3789.1997

DO - 10.1128/jb.179.11.3786-3789.1997

M3 - Article

C2 - 9171431

AN - SCOPUS:0030998934

SN - 0021-9193

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SP - 3786

EP - 3789

JO - Journal of Bacteriology

JF - Journal of Bacteriology

IS - 11

ER -

Membrane topology of the metal-tetracycline/H⁺ antiporter TetA(K) from Staphylococcus aureus

Abstract

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