Membrane–drug interactions studied using model membrane systems

Jacqueline Knobloch; Daniel Suhendro; Julius Zieleniecki; Joseph Shapter; Ingo Koper

doi:10.1016/j.sjbs.2015.03.007

Membrane–drug interactions studied using model membrane systems

Jacqueline Knobloch, Daniel Suhendro, Julius Zieleniecki, Joseph Shapter, Ingo Koper

Research output: Contribution to journal › Article › peer-review

67 Citations (Scopus)

Abstract

The direct interaction of drugs with the cell membrane is often neglected when drug effects are studied. Systematic investigations are hindered by the complexity of the natural membrane and model membrane systems can offer a useful alternative. Here some examples are reviewed of how model membrane architectures including vesicles, Langmuir monolayers and solid supported membranes can be used to investigate the effects of drug molecules on the membrane structure, and how these interactions can translate into effects on embedded membrane proteins.

Original language	English
Pages (from-to)	714-718
Number of pages	5
Journal	SAUDI JOURNAL OF BIOLOGICAL SCIENCES
Volume	22
Issue number	6
DOIs	https://doi.org/10.1016/j.sjbs.2015.03.007
Publication status	Published - Nov 2015

Keywords

Drug-membrane interaction
Drugs
Model membranes
Review

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10.1016/j.sjbs.2015.03.007

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abstract = "The direct interaction of drugs with the cell membrane is often neglected when drug effects are studied. Systematic investigations are hindered by the complexity of the natural membrane and model membrane systems can offer a useful alternative. Here some examples are reviewed of how model membrane architectures including vesicles, Langmuir monolayers and solid supported membranes can be used to investigate the effects of drug molecules on the membrane structure, and how these interactions can translate into effects on embedded membrane proteins.",

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AU - Suhendro, Daniel

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AU - Shapter, Joseph

AU - Koper, Ingo

PY - 2015/11

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KW - Drugs

KW - Model membranes

KW - Review

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Membrane–drug interactions studied using model membrane systems

Abstract

Keywords

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