Membrane–drug interactions studied using model membrane systems

Jacqueline Knobloch, Daniel Suhendro, Julius Zieleniecki, Joseph Shapter, Ingo Koper

    Research output: Contribution to journalArticle

    33 Citations (Scopus)

    Abstract

    The direct interaction of drugs with the cell membrane is often neglected when drug effects are studied. Systematic investigations are hindered by the complexity of the natural membrane and model membrane systems can offer a useful alternative. Here some examples are reviewed of how model membrane architectures including vesicles, Langmuir monolayers and solid supported membranes can be used to investigate the effects of drug molecules on the membrane structure, and how these interactions can translate into effects on embedded membrane proteins.

    Original languageEnglish
    Pages (from-to)714-718
    Number of pages5
    JournalSAUDI JOURNAL OF BIOLOGICAL SCIENCES
    Volume22
    Issue number6
    DOIs
    Publication statusPublished - Nov 2015

    Keywords

    • Drug-membrane interaction
    • Drugs
    • Model membranes
    • Review

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