TY - JOUR
T1 - Membrane–drug interactions studied using model membrane systems
AU - Knobloch, Jacqueline
AU - Suhendro, Daniel
AU - Zieleniecki, Julius
AU - Shapter, Joseph
AU - Koper, Ingo
PY - 2015/11
Y1 - 2015/11
N2 - The direct interaction of drugs with the cell membrane is often neglected when drug effects are studied. Systematic investigations are hindered by the complexity of the natural membrane and model membrane systems can offer a useful alternative. Here some examples are reviewed of how model membrane architectures including vesicles, Langmuir monolayers and solid supported membranes can be used to investigate the effects of drug molecules on the membrane structure, and how these interactions can translate into effects on embedded membrane proteins.
AB - The direct interaction of drugs with the cell membrane is often neglected when drug effects are studied. Systematic investigations are hindered by the complexity of the natural membrane and model membrane systems can offer a useful alternative. Here some examples are reviewed of how model membrane architectures including vesicles, Langmuir monolayers and solid supported membranes can be used to investigate the effects of drug molecules on the membrane structure, and how these interactions can translate into effects on embedded membrane proteins.
KW - Drug-membrane interaction
KW - Drugs
KW - Model membranes
KW - Review
UR - http://www.scopus.com/inward/record.url?scp=84945453858&partnerID=8YFLogxK
U2 - 10.1016/j.sjbs.2015.03.007
DO - 10.1016/j.sjbs.2015.03.007
M3 - Article
VL - 22
SP - 714
EP - 718
JO - SAUDI JOURNAL OF BIOLOGICAL SCIENCES
JF - SAUDI JOURNAL OF BIOLOGICAL SCIENCES
SN - 1319-562X
IS - 6
ER -