Mepitel film for the prevention and treatment of acute radiation dermatitis in breast cancer: a systematic review and meta-analysis of randomized controlled trials

Saba Shariati, Tara Behroozian, Samantha Kennedy, Saverio Caini, Patries M. Herst, Liying Zhang, Keyue Ding, Irene Karam, Corina van den Hurk, Julie Ryan Wolf, Shing Fung Lee, Henry Wong, Adrian Wai Chan, Mami Ogita, Jason C. Ye, Raymond J. Chan, Milena Gojsevic, Thenugaa Rajeswaran, Pierluigi Bonomo, Edward Chow

Research output: Contribution to journalReview articlepeer-review

4 Citations (Scopus)

Abstract

PURPOSE: This systematic review and meta-analysis aimed to evaluate the efficacy of Mepitel film in preventing or treating acute radiation dermatitis (RD) in patients with breast cancer in randomized controlled trials (RCTs). 

METHODS: Embase, APA PsychInfo, Journals@Ovid Full Text, Ovid MEDLINE, PubMed, and Cochrane Trials were searched until December 12, 2022, to identify RCTs on the use of Mepitel film for preventing or treating acute RD from breast cancer radiotherapy. Per-protocol analysis was used to compare outcomes, calculate pooled effect sizes, odds ratio (OR), and 95% confidence intervals (CI), and to create forest plots using random effects analysis in RevMan 5.4. 

RESULTS: Three RCTs were included in this review. Mepitel film significantly reduced the incidence of grade 3 RD (OR 0.15 95% CI 0.06, 0.37, p<0.0001) and grade 2 or 3 RD (OR 0.16 95% CI 0.04, 0.65, p=0.01) as scored on either the CTCAE or the RTOG scale. Additionally, Mepitel film significantly reduced RISRAS mean scores assessed by patients and combined researcher and patient (standardized mean difference (SMD) -7.59, 95% CI -14.42, -0.76, p=0.03; SMD -15.36, 95% CI -30.01, -0.71 p=0.04) but not the researcher component of the assessment tool (SMD -17.55, 95% CI -36.94, 1.84, p=0.08). 

CONCLUSION: Mepitel film reduced the incidence of acute RD and improved patient-reported outcomes with minimal side effects, the main one being itchiness. Future research should assess the feasibility of Mepitel film with respect to specific patient-reported outcomes such as health-related quality of life issues associated with its use.

Original languageEnglish
Article number524
Number of pages14
JournalSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
Volume31
Issue number9
Early online date16 Aug 2023
DOIs
Publication statusPublished - Sept 2023

Keywords

  • acute radiation dermatitis
  • breast cancer
  • Mepitel film
  • patient reported outcomes, meta-analysis
  • skin toxicity
  • systematic review

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