Mepitel Film for the prevention of acute radiation dermatitis in head and neck cancer: a systematic review and meta-analysis of randomized controlled trials

Shing Fung Lee, Henry C.Y. Wong, Adrian Wai Chan, Saverio Caini, Saba Shariati, Dirk Rades, Raymond J. Chan, Samantha K.F. Kennedy, Julie Ryan Wolf, Corina van den Hurk, Tara Behroozian, Pierluigi Bonomo, Francis C.H. Ho, Edward Chow, Patries Herst

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)

Abstract

Purpose: This systematic review and meta-analysis evaluates the efficacy of Mepitel Film in preventing acute radiation dermatitis (RD) in patients with head and neck cancer (HNC) across randomized controlled trials (RCTs). 

Methods: Embase, MEDLINE, and Cochrane Central Register of Controlled Trials were searched on 5 March 2023 to identify relevant RCTs. RD assessment tools and outcomes were compared across studies. Pooled effect sizes and 95% confidence intervals (CI) were estimated based on random-effects analysis using RevMan 5.4. 

Results: Three RCTs conducted between 2018 and 2020 were included. Mepitel Film decreased RD severity when compared to Sorbolene or Biafine but not when compared to mometasone. A per-protocol analysis of two of the trials revealed that, overall, Mepitel Film significantly reduced the incidence of grade 2–3 RD (odds ratio (OR), 0.24; 95% CI, 0.09–0.65; p = 0.005) and moist desquamation (OR, 0.21; 95% CI, 0.10–0.46; p < 0.0001) and decreased average patient, researcher, and combined components of the Radiation-Induced Skin Reaction Assessment Scale (the standardized mean difference (SMD) for patient ratings, − 2.56; 95% CI, − 3.15 to − 1.96, p < 0.00001; SMD for researcher ratings, − 3.47; 95% CI, − 6.63 to − 0.31, p = 0.03; SMD for combined scores, − 3.68; 95% CI, − 6.43 to − 0.92, p = 0.009). Noted issues with Mepitel Film included itchiness and poor adherence. 

Conclusion: While there were discrepancies across studies, Mepitel Film demonstrated a decrease in the incidence of grade 2–3 RD and moist desquamation. These findings emphasize the need for further examining Mepitel Film’s efficacy across diverse patient groups and the importance of standardizing RD severity assessment methodologies and control arms.

Original languageEnglish
Article number527
Number of pages12
JournalSupportive Care in Cancer
Volume31
Issue number9
Early online date18 Aug 2023
DOIs
Publication statusPublished - Sept 2023

Keywords

  • Acute radiation dermatitis
  • Head and neck cancer
  • Mepitel Film
  • Meta-analysis
  • Skin toxicity
  • Systematic review

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