TY - JOUR
T1 - Meta-analysis of neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio in rheumatoid arthritis
AU - Erre, Gian Luca
AU - Paliogiannis, Panagiotis
AU - Castagna, Floriana
AU - Mangoni, Arduino Aleksander
AU - Carru, Ciriaco
AU - Passiu, Giuseppe
AU - Zinellu, Angelo
PY - 2019/1
Y1 - 2019/1
N2 - Background: We conducted a meta-analysis to review the available evidence regarding the associations between peripheral blood neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) and the presence of rheumatoid arthritis (RA). Methods: PubMed, Web of Science and Scopus, from inception to January 2018, were searched for studies reporting on NLR and PLR in RA in comparison with healthy subjects. Standardized mean difference (SMD) was calculated with a confidence interval (CI) of 95%. Results: Thirteen NLR studies (1550 RA patients and 1128 healthy controls) and 8 PLR studies (380 RA patients and 305 healthy controls) were included in the meta-analysis. NLR and PLR were significantly higher in patients with RA when compared to controls (SMD = 0.79, 95% CI 0.55-1.03; P < 0.001 and SMD = 0.66, 95% CI 0.43-0.88; P < 0.001, respectively). Conclusions: The NLR and PLR are significantly associated with the presence of RA. Further studies are required to ascertain the potential clinical use of these simple and relatively inexpensive markers in RA diagnosis.
AB - Background: We conducted a meta-analysis to review the available evidence regarding the associations between peripheral blood neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) and the presence of rheumatoid arthritis (RA). Methods: PubMed, Web of Science and Scopus, from inception to January 2018, were searched for studies reporting on NLR and PLR in RA in comparison with healthy subjects. Standardized mean difference (SMD) was calculated with a confidence interval (CI) of 95%. Results: Thirteen NLR studies (1550 RA patients and 1128 healthy controls) and 8 PLR studies (380 RA patients and 305 healthy controls) were included in the meta-analysis. NLR and PLR were significantly higher in patients with RA when compared to controls (SMD = 0.79, 95% CI 0.55-1.03; P < 0.001 and SMD = 0.66, 95% CI 0.43-0.88; P < 0.001, respectively). Conclusions: The NLR and PLR are significantly associated with the presence of RA. Further studies are required to ascertain the potential clinical use of these simple and relatively inexpensive markers in RA diagnosis.
KW - biomarkers
KW - meta-analysis
KW - neutrophil-to-lymphocyte ratio
KW - platelet-to-lymphocyte ratio
KW - rheumatoid arthritis
KW - systematic review
UR - http://www.scopus.com/inward/record.url?scp=85056096720&partnerID=8YFLogxK
U2 - https://doi.org/10.1111/eci.13037
DO - https://doi.org/10.1111/eci.13037
M3 - Review article
C2 - 30316204
VL - 49
JO - EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
JF - EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
SN - 0014-2972
IS - 1
M1 - e13037
ER -