Abstract
A method of modulating the growth of a cell, such as a neoplastic or malignant cell from the colon, stomach, lung, brain, bone, esophagus, pancreas, breast, ovary or uterus includes contacting the cell with an agent for a time and under conditions sufficient to modulate the functional activity of sphingosine kinase in which down-regulation of the functional activity of the sphingosine kinase down-regulates growth of the cells and up-regulation of the functional activity of this sphingosine kinase up-regulates the growth of the cell. The down-regulation can reduce the functional activity of this sphingosine kinase to an oncogenic ineffective level. Agents useful in the invention include N,N-dimethylspingosine and DL-threo-dihydrosphingosine
| Original language | English |
|---|---|
| Patent number | US 2005/0009732 A1 |
| IPC | (IPC1-7): A61K38/17 |
| Filing date | 19/02/04 |
| Publication status | Published - 15 Jan 2005 |
Keywords
- sphingosine kinase 1