Methylated arginines and nitric oxide in end-stage renal disease: impact of inflammation, oxidative stress and haemodialysis

Nadia Bouteldja, Richard Woodman, Christopher Hewitson, Enric Domingo, Jeffrey Barbara, Arduino Mangoni

    Research output: Contribution to journalArticle

    4 Citations (Scopus)

    Abstract

    Objectives: To determine whether inflammation (C-reactive protein, CRP), oxidative stress (malondialdehyde, MDA) or haemodialysis (HD) affect associations between asymmetric (ADMA), symmetric (SDMA) dimethylarginine, NG-monomethyl-L-arginine (L-NMMA) and nitrite/nitrate (NOx) in end-stage renal disease (ESRD). Method: Metabolites were measured pre-HD, after 1 hour and end-HD in 40 ESRD patients (age 63 ± 14 years). Results: Positive associations between NOx and ADMA (p = 0.04), SDMA (p < 0.001) and L-NMMA (p = 0.04) were observed pre-HD. Associations weakened during HD but were not significantly influenced by CRP or MDA. Conclusions: HD, oxidative stress or inflammation did not significantly affect the positive associations between methylated arginines and NOx in ESRD.

    Original languageEnglish
    Pages (from-to)357-364
    Number of pages8
    JournalBiomarkers
    Volume18
    Issue number4
    DOIs
    Publication statusPublished - 2013

    Keywords

    • Cardiovascular disease
    • Metabol(n)omics
    • Renal disease

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