Micro-ribonucleic acids in head and neck cancer: an introduction

Ishan Gunawardena, Jude Fitzgerald, Alexander Morley, Damian Hussey, Charmaine Woods, Andrew Carney

    Research output: Contribution to journalArticlepeer-review

    5 Citations (Scopus)

    Abstract

    Head and neck cancer is the sixth most common cancer worldwide. Advances in management have not greatly altered overall survival. Over the last decade, there have been significant scientific advances in our knowledge of cell cycle regulation and the complex oncogenic processes. MicroRNAs are small, non-coding RNAs which are integral to the regulation of gene expression and which play a part in carcinogenesis. The literature on the role of microRNA in head and neck cancer is reviewed. To introduce the role and significance of microRNAs in head and neck cancer. The possibilities of incorporating microRNAs into clinical practice are discussed, including their potential role in diagnosis, prognosis, prediction of metastatic spread, therapy and tumour surveillance. Discoveries in expression profiling of microRNA in head and neck oncology promise advancements in the diagnosis, prognosis and therapy of these cancers.

    Original languageEnglish
    Pages (from-to)S2-S7
    Number of pages6
    JournalJournal of Laryngology and Otology
    Volume127 Suppl 2
    Issue numberSuppl 2
    DOIs
    Publication statusPublished - Jul 2013

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