Microfluidic fabrication of cationic curcumin nanoparticles as an anti-cancer agent.

Selvi Dev, Praseetha Prabhakaran, Luis Filgueira, K Iyer, Colin Raston

    Research output: Contribution to journalArticlepeer-review

    30 Citations (Scopus)

    Abstract

    Curcumin nanoparticles of less than 50 nm in diameter are accessible using a continuous flow microfluidic rotating tube processor (RTP) under scalable conditions, at room temperature. A mixture of DDAB and Pluronic F127 renders higher stability of the curcumin nanoparticles in physiological pH 7.4 for up to eight hours. The nanoparticles have enhanced cytotoxicity in estrogens receptor negative and positive breast cancer cell lines compared with free curcumin.

    Original languageEnglish
    Pages (from-to)2575-2579
    Number of pages5
    JournalNanoscale
    Volume4
    Issue number8
    DOIs
    Publication statusPublished - 21 Apr 2012

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