MICROINJECTION OF KAINIC ACID INTO THE ROSTRAL VENTROLATERAL MEDULLA CAUSES HYPERTENSION AND RELEASE OF NEUROPEPTIDE Y‐LIKE IMMUNOREACTIVITY FROM RABBIT SPINAL CORD

M. J. Morris; P. M. Pilowsky; J. B. Minson; M. J. West; J. P. Chalmers

doi:10.1111/j.1440-1681.1987.tb00966.x

MICROINJECTION OF KAINIC ACID INTO THE ROSTRAL VENTROLATERAL MEDULLA CAUSES HYPERTENSION AND RELEASE OF NEUROPEPTIDE Y‐LIKE IMMUNOREACTIVITY FROM RABBIT SPINAL CORD

M. J. Morris, P. M. Pilowsky, J. B. Minson, M. J. West, J. P. Chalmers

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Abstract

SUMMARY 1. Microinjections of kainic acid were made into the pressor area of the rostral ventrolateral medulla oblongata of anaesthetized rabbits, in the region of the C1 adrenaline‐containing neurons. 2. Over the 65 min following the microinjection, there was a significant increase in blood pressure, as well as an increase in the release of neuropeptide Y‐like immunoreactivity into the spinal subarachnoid space. 3. These data provide evidence for a functional bulbospinal neuropeptide Y‐containing projection which may be responsible for mediating the pressor effects of stimulation of the rostral ventrolateral medulla.

Original language	English
Pages (from-to)	127-132
Number of pages	6
Journal	Clinical and Experimental Pharmacology and Physiology
Volume	14
Issue number	2
DOIs	https://doi.org/10.1111/j.1440-1681.1987.tb00966.x
Publication status	Published - Feb 1987

Keywords

blood pressure
bulbospinal neurons
neuropeptide Y
spinal cord perfusion
ventrolateral medulla.

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Morris, M. J., Pilowsky, P. M., Minson, J. B., West, M. J., & Chalmers, J. P. (1987). MICROINJECTION OF KAINIC ACID INTO THE ROSTRAL VENTROLATERAL MEDULLA CAUSES HYPERTENSION AND RELEASE OF NEUROPEPTIDE Y‐LIKE IMMUNOREACTIVITY FROM RABBIT SPINAL CORD. Clinical and Experimental Pharmacology and Physiology, 14(2), 127-132. https://doi.org/10.1111/j.1440-1681.1987.tb00966.x

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title = "MICROINJECTION OF KAINIC ACID INTO THE ROSTRAL VENTROLATERAL MEDULLA CAUSES HYPERTENSION AND RELEASE OF NEUROPEPTIDE Y‐LIKE IMMUNOREACTIVITY FROM RABBIT SPINAL CORD",

abstract = "SUMMARY 1. Microinjections of kainic acid were made into the pressor area of the rostral ventrolateral medulla oblongata of anaesthetized rabbits, in the region of the C1 adrenaline‐containing neurons. 2. Over the 65 min following the microinjection, there was a significant increase in blood pressure, as well as an increase in the release of neuropeptide Y‐like immunoreactivity into the spinal subarachnoid space. 3. These data provide evidence for a functional bulbospinal neuropeptide Y‐containing projection which may be responsible for mediating the pressor effects of stimulation of the rostral ventrolateral medulla.",

keywords = "blood pressure, bulbospinal neurons, neuropeptide Y, spinal cord perfusion, ventrolateral medulla.",

author = "Morris, {M. J.} and Pilowsky, {P. M.} and Minson, {J. B.} and West, {M. J.} and Chalmers, {J. P.}",

year = "1987",

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doi = "10.1111/j.1440-1681.1987.tb00966.x",

language = "English",

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journal = "Clinical and Experimental Pharmacology and Physiology",

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Morris, MJ, Pilowsky, PM, Minson, JB, West, MJ & Chalmers, JP 1987, 'MICROINJECTION OF KAINIC ACID INTO THE ROSTRAL VENTROLATERAL MEDULLA CAUSES HYPERTENSION AND RELEASE OF NEUROPEPTIDE Y‐LIKE IMMUNOREACTIVITY FROM RABBIT SPINAL CORD', Clinical and Experimental Pharmacology and Physiology, vol. 14, no. 2, pp. 127-132. https://doi.org/10.1111/j.1440-1681.1987.tb00966.x

MICROINJECTION OF KAINIC ACID INTO THE ROSTRAL VENTROLATERAL MEDULLA CAUSES HYPERTENSION AND RELEASE OF NEUROPEPTIDE Y‐LIKE IMMUNOREACTIVITY FROM RABBIT SPINAL CORD. / Morris, M. J.; Pilowsky, P. M.; Minson, J. B. et al.
In: Clinical and Experimental Pharmacology and Physiology, Vol. 14, No. 2, 02.1987, p. 127-132.

Research output: Contribution to journal › Article › peer-review

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AU - Morris, M. J.

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N2 - SUMMARY 1. Microinjections of kainic acid were made into the pressor area of the rostral ventrolateral medulla oblongata of anaesthetized rabbits, in the region of the C1 adrenaline‐containing neurons. 2. Over the 65 min following the microinjection, there was a significant increase in blood pressure, as well as an increase in the release of neuropeptide Y‐like immunoreactivity into the spinal subarachnoid space. 3. These data provide evidence for a functional bulbospinal neuropeptide Y‐containing projection which may be responsible for mediating the pressor effects of stimulation of the rostral ventrolateral medulla.

AB - SUMMARY 1. Microinjections of kainic acid were made into the pressor area of the rostral ventrolateral medulla oblongata of anaesthetized rabbits, in the region of the C1 adrenaline‐containing neurons. 2. Over the 65 min following the microinjection, there was a significant increase in blood pressure, as well as an increase in the release of neuropeptide Y‐like immunoreactivity into the spinal subarachnoid space. 3. These data provide evidence for a functional bulbospinal neuropeptide Y‐containing projection which may be responsible for mediating the pressor effects of stimulation of the rostral ventrolateral medulla.

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KW - neuropeptide Y

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MICROINJECTION OF KAINIC ACID INTO THE ROSTRAL VENTROLATERAL MEDULLA CAUSES HYPERTENSION AND RELEASE OF NEUROPEPTIDE Y‐LIKE IMMUNOREACTIVITY FROM RABBIT SPINAL CORD

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