MICROINJECTION OF KAINIC ACID INTO THE ROSTRAL VENTROLATERAL MEDULLA CAUSES HYPERTENSION AND RELEASE OF NEUROPEPTIDE Y‐LIKE IMMUNOREACTIVITY FROM RABBIT SPINAL CORD

M. J. Morris, P. M. Pilowsky, J. B. Minson, M. J. West, J. P. Chalmers

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    24 Citations (Scopus)

    Abstract

    SUMMARY 1. Microinjections of kainic acid were made into the pressor area of the rostral ventrolateral medulla oblongata of anaesthetized rabbits, in the region of the C1 adrenaline‐containing neurons. 2. Over the 65 min following the microinjection, there was a significant increase in blood pressure, as well as an increase in the release of neuropeptide Y‐like immunoreactivity into the spinal subarachnoid space. 3. These data provide evidence for a functional bulbospinal neuropeptide Y‐containing projection which may be responsible for mediating the pressor effects of stimulation of the rostral ventrolateral medulla.

    Original languageEnglish
    Pages (from-to)127-132
    Number of pages6
    JournalClinical and Experimental Pharmacology and Physiology
    Volume14
    Issue number2
    DOIs
    Publication statusPublished - Feb 1987

    Keywords

    • blood pressure
    • bulbospinal neurons
    • neuropeptide Y
    • spinal cord perfusion
    • ventrolateral medulla.

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