TY - JOUR
T1 - Microneedle hierarchical structure construction for promoting multi-stage wound healing
AU - Zhang, Rui
AU - Tang, Pengfei
AU - Chen, Zhenfeng
AU - Tang, Ming
AU - Yang, Kun
AU - Tang, Youhong
AU - Zhang, Hongping
AU - Wang, Qingyuan
PY - 2025/4/15
Y1 - 2025/4/15
N2 - As a new type of drug delivery system, microneedle have received extensive attention in wound healing due to their penetrability, painlessness, and high drug delivery efficiency. However, microneedle are often unable to penetrate the skin completely due to the limitations of the skin's mechanical properties, resulting in low drug delivery efficiency during wound repair. Therefore, it is particularly important to optimize the multi-level structural design of microneedles. This article systematically summarizes the multi-level structural design of microneedles that promote wound healing, including the structural parameters of a single microneedle, microneedle array design, and microneedle system structural optimization. It also summarizes the research progress on the functional design of microneedle systems at various stages of wound repair. This paper reviews the current status and limitations of microneedle patch design, and provides theoretical guidance for the design of smart microneedle wound management/healing.
AB - As a new type of drug delivery system, microneedle have received extensive attention in wound healing due to their penetrability, painlessness, and high drug delivery efficiency. However, microneedle are often unable to penetrate the skin completely due to the limitations of the skin's mechanical properties, resulting in low drug delivery efficiency during wound repair. Therefore, it is particularly important to optimize the multi-level structural design of microneedles. This article systematically summarizes the multi-level structural design of microneedles that promote wound healing, including the structural parameters of a single microneedle, microneedle array design, and microneedle system structural optimization. It also summarizes the research progress on the functional design of microneedle systems at various stages of wound repair. This paper reviews the current status and limitations of microneedle patch design, and provides theoretical guidance for the design of smart microneedle wound management/healing.
KW - Bionic structure
KW - Functional microneedle
KW - Structural design
KW - Wound repair
UR - http://www.scopus.com/inward/record.url?scp=105000117289&partnerID=8YFLogxK
U2 - 10.1016/j.ijpharm.2025.125474
DO - 10.1016/j.ijpharm.2025.125474
M3 - Review article
C2 - 40086651
AN - SCOPUS:105000117289
SN - 0378-5173
VL - 674
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
M1 - 125474
ER -