Micropatterned Arrays of Porous Silicon: Toward Sensory Biointerfaces

Benjamin Flavel, Martin Sweetman, Cameron Shearer, Joseph Shapter, Nicolas Voelcker

    Research output: Contribution to journalArticlepeer-review

    35 Citations (Scopus)

    Abstract

    We describe the fabrication of arrays of porous silicon spots by means of photolithography where a positive photoresist serves as a mask during the anodization process. In particular, photoluminescent arrays and porous silicon spots suitable for further chemical modification and the attachment of human cells were created. The produced arrays of porous silicon were chemically modified by means of a thermal hydrosilylation reaction that facilitated immobilization of the fluorescent dye lissamine, and alternatively, the cell adhesion peptide arginine-glycine-aspartic acid-serine. The latter modification enabled the selective attachment of human lens epithelial cells on the peptide functionalized regions of the patterns. This type of surface patterning, using etched porous silicon arrays functionalized with biological recognition elements, presents a new format of interfacing porous silicon with mammalian cells. Porous silicon arrays with photoluminescent properties produced by this patterning strategy also have potential applications as platforms for in situ monitoring of cell behavior.

    Original languageEnglish
    Pages (from-to)2463-2471
    Number of pages9
    JournalACS Applied Materials & Interfaces
    Volume3
    Issue number7
    DOIs
    Publication statusPublished - 27 Jul 2011

    Keywords

    • biointerface
    • cell adhesion
    • photolithography
    • photoluminescence
    • porous silicon

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