TY - JOUR
T1 - MicroRNAs, development of Barrett's esophagus, and progression to esophageal adenocarcinoma
AU - Smith, Cameron
AU - Watson, David
AU - Michael, Michael
AU - Hussey, Damian
PY - 2010/2/7
Y1 - 2010/2/7
N2 - Barrett's esophagus is a premalignant condition caused by gastroesophageal reflux. Once developed, it can progress through varying grades of dysplasia to esophageal adenocarcinoma. Whilst it is well accepted that Barrett's esophagus is caused by gastroesophageal reflux, the molecular mechanisms of its pathogenesis and progression to cancer remain unclear. MicroRNAs (miRNAs) are short segments of RNA that have been shown to control the expression of many human genes. They have been implicated in most cellular processes, and the role of miRNAs in disease development is becoming increasingly evident. Understanding altered miRNA expression is likely to help unravel the molecular mechanisms that underpin the development of Barrett's esophagus and its progression to cancer.
AB - Barrett's esophagus is a premalignant condition caused by gastroesophageal reflux. Once developed, it can progress through varying grades of dysplasia to esophageal adenocarcinoma. Whilst it is well accepted that Barrett's esophagus is caused by gastroesophageal reflux, the molecular mechanisms of its pathogenesis and progression to cancer remain unclear. MicroRNAs (miRNAs) are short segments of RNA that have been shown to control the expression of many human genes. They have been implicated in most cellular processes, and the role of miRNAs in disease development is becoming increasingly evident. Understanding altered miRNA expression is likely to help unravel the molecular mechanisms that underpin the development of Barrett's esophagus and its progression to cancer.
KW - Barrett's esophagus
KW - Esophageal adenocarcinoma
KW - MicroRNA
KW - Transdifferentiation
KW - Tumour suppressor
UR - http://www.scopus.com/inward/record.url?scp=76549130377&partnerID=8YFLogxK
U2 - 10.3748/wjg.v16.i5.531
DO - 10.3748/wjg.v16.i5.531
M3 - Article
VL - 16
SP - 531
EP - 537
JO - World journal of gastroenterology
JF - World journal of gastroenterology
SN - 1007-9327
IS - 5
ER -