Abstract
We appreciate Coen Stehouwer and Thomas van Sloten's comments on the clinical relevance of the endpoints in our meta-analysis of individual participant data from the four large trials of more versus less intensive glucose control in patients with type 2 diabetes. The selection of endpoints followed a rigorous, prespecified process that included foremost: consideration of clinical relevance, use of common definitions, standardised ascertainment, and data availability across the trials.
Original language | English |
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Pages (from-to) | 580 |
Number of pages | 1 |
Journal | The Lancet Diabetes and Endocrinology |
Volume | 5 |
Issue number | 8 |
DOIs | |
Publication status | Published - Aug 2017 |
Externally published | Yes |
Keywords
- Correspondence
- reply
- response
- type 2 diabetes
- Microvascular outcomes
- less intensive glucose control
- selection of endpoints
- composite endpoints
- macroalbuminuria
- retinopathy