Mindfulness training and inflammatory cytokine levels in chronic tension-type headache

Stuart Cathcart, Chris Della Vedova, Maarten Immink, Michael Proeve, John Hayball

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


In this chapter we examine the effects of mindfulness training on serum proinflammatory cytokine levels in chronic tension-type headache (CTH) sufferers. Method: Forty-three CTH sufferers participated in a randomized wait-list controlled trial of a mindfulness intervention for headache. Serum concentrations of cytokines IL1-β, IL-2, IL-6, IL-8, IL-12, IL-18, IFN-γ, MCP-1 and TNF-α were measured before and after treatment/wait-list control conditions. Results: Repeated Measures Analysis of Variance revealed that IL1-β, IL-6, IL-8, MCP-1 and TNF-α decreased from pre to post assessments in the treatment and wait-list groups, with no group or group x time effects. Conclusions: Mindfulness training compared to a wait-list control condition does not reduce serum cytokine levels in CTH sufferers.

Original languageEnglish
Title of host publicationDisability and Chronic Disease
EditorsJoav Merrick, Shoshana Aspler, Mohammed Morad
PublisherNova Science Publishers, Inc.
Number of pages6
ISBN (Electronic)9781629483078
ISBN (Print)9781629482880
Publication statusPublished - 2014
Externally publishedYes

Publication series

NameDisability Studies
PublisherNova Science Publishers


  • mindfulness training
  • serum proinflammatory cytokine levels
  • chronic tension-type headache (CTH)
  • TNF-α
  • ethylenediaminetetracetic acid (EDT A)
  • Mindfulness-Based Stress Reduction (MBSR)
  • Mindfulness Based Cognitive Therapy (MBCT)


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