Mini-review: efficacy of lytic bacteriophages on multispecies biofilms

Legesse Geredew Kifelew, James G. Mitchell, Peter Speck

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)


There is potential for phages to prevent and control bacterial biofilms, but few studies have examined the effect of phages on the multispecies biofilms that characterize most bacterial infections. This paper reviews the mechanism of action of phages, the evidence supporting the view that phage therapy will be effective against bacterial targets and the opposite viewpoint, phage application approaches, and the comparative advantage of phage therapy in multispecies biofilms. The few reports measuring the actions of lytic phages against multispecies biofilms are also reviewed. The authors are cautiously optimistic about the application of phages against their targets when in multispecies biofilms because some lysis mechanisms do not require species specificity.

Original languageEnglish
Pages (from-to)472-481
Number of pages10
Issue number4
Publication statusPublished - 21 Apr 2019


  • Bacteria
  • biofilm
  • efficacy
  • multispecies
  • phage
  • susceptible


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