Mitochondrial haplogroups are not associated with diabetic retinopathy in a large Australian and British Caucasian sample.

Ebony Liu; Georgia Kaidonis; Mark Gillies; Sotoodeh Abhary; Rohan Essex; John H Chang; Bishwanath Pal; Mark Daniell; Stewart Lake; Jolly Gilhotra; Nikolai Petrovsky; Alex W Hewitt; Alicia Jenkins; Ecosse L Lamoureux; Jonathan M Gleadle; Kathryn P Burdon; Jamie Craig

doi:10.1038/s41598-018-37388-8

Mitochondrial haplogroups are not associated with diabetic retinopathy in a large Australian and British Caucasian sample.

Ebony Liu, Georgia Kaidonis, Mark Gillies, Sotoodeh Abhary, Rohan Essex, John H Chang, Bishwanath Pal, Mark Daniell, Stewart Lake, Jolly Gilhotra, Nikolai Petrovsky, Alex W Hewitt, Alicia Jenkins, Ecosse L Lamoureux, Jonathan M Gleadle, Kathryn P Burdon, Jamie Craig

College of Medicine and Public Health

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Abstract

Mitochondrial haplogroups H1, H2 and UK have previously been reported to be associated with proliferative diabetic retinopathy (PDR) in Caucasian patients with diabetes. We aimed to replicate this finding with a larger sample and expand the analysis to include different severities of DR, and diabetic macular edema (DME). Caucasian participants (n = 2935) with either type 1 or type 2 diabetes from the Australian Registry of Advanced Diabetic Retinopathy were enrolled in this study. Twenty-two mitochondrial single nucleotide polymorphisms were genotyped by MassArray and haplogroups reconstructed using Haplogrep. Chi square tests and logistic regressions were used to test associations between haplogroup and DR phenotypes including any DR, non-proliferative DR (NPDR), proliferative DR (PDR) and DME. After stratifying the samples in type 1 and type 2 diabetes groups, and adjusting for sex, age, diabetes duration, concurrent HbA1c and hypertension, neither haplogroups H1, H2, UK, K or JT were associated with any DR, NPDR, PDR or DME.

Original language	English
Article number	612
Number of pages	7
Journal	Scientific Reports
Volume	9
Issue number	1
DOIs	https://doi.org/10.1038/s41598-018-37388-8
Publication status	Published - 24 Feb 2019

Keywords

Mitochondrial haplogroup
diabetic retinopathy
Australian
British
caucasian sample

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Liu, E., Kaidonis, G., Gillies, M., Abhary, S., Essex, R., Chang, J. H., Pal, B., Daniell, M., Lake, S., Gilhotra, J., Petrovsky, N., Hewitt, A. W., Jenkins, A., Lamoureux, E. L., Gleadle, J. M., Burdon, K. P., & Craig, J. (2019). Mitochondrial haplogroups are not associated with diabetic retinopathy in a large Australian and British Caucasian sample. Scientific Reports, 9(1), Article 612. https://doi.org/10.1038/s41598-018-37388-8

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title = "Mitochondrial haplogroups are not associated with diabetic retinopathy in a large Australian and British Caucasian sample.",

abstract = "Mitochondrial haplogroups H1, H2 and UK have previously been reported to be associated with proliferative diabetic retinopathy (PDR) in Caucasian patients with diabetes. We aimed to replicate this finding with a larger sample and expand the analysis to include different severities of DR, and diabetic macular edema (DME). Caucasian participants (n = 2935) with either type 1 or type 2 diabetes from the Australian Registry of Advanced Diabetic Retinopathy were enrolled in this study. Twenty-two mitochondrial single nucleotide polymorphisms were genotyped by MassArray and haplogroups reconstructed using Haplogrep. Chi square tests and logistic regressions were used to test associations between haplogroup and DR phenotypes including any DR, non-proliferative DR (NPDR), proliferative DR (PDR) and DME. After stratifying the samples in type 1 and type 2 diabetes groups, and adjusting for sex, age, diabetes duration, concurrent HbA1c and hypertension, neither haplogroups H1, H2, UK, K or JT were associated with any DR, NPDR, PDR or DME.",

keywords = "Mitochondrial haplogroup, diabetic retinopathy, Australian, British, caucasian sample",

author = "Ebony Liu and Georgia Kaidonis and Mark Gillies and Sotoodeh Abhary and Rohan Essex and Chang, {John H} and Bishwanath Pal and Mark Daniell and Stewart Lake and Jolly Gilhotra and Nikolai Petrovsky and Hewitt, {Alex W} and Alicia Jenkins and Lamoureux, {Ecosse L} and Gleadle, {Jonathan M} and Burdon, {Kathryn P} and Jamie Craig",

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Liu, E, Kaidonis, G, Gillies, M, Abhary, S, Essex, R, Chang, JH, Pal, B, Daniell, M, Lake, S, Gilhotra, J, Petrovsky, N, Hewitt, AW, Jenkins, A, Lamoureux, EL, Gleadle, JM, Burdon, KP & Craig, J 2019, 'Mitochondrial haplogroups are not associated with diabetic retinopathy in a large Australian and British Caucasian sample.', Scientific Reports, vol. 9, no. 1, 612. https://doi.org/10.1038/s41598-018-37388-8

TY - JOUR

T1 - Mitochondrial haplogroups are not associated with diabetic retinopathy in a large Australian and British Caucasian sample.

AU - Liu, Ebony

AU - Kaidonis, Georgia

AU - Gillies, Mark

AU - Abhary, Sotoodeh

AU - Essex, Rohan

AU - Chang, John H

AU - Pal, Bishwanath

AU - Daniell, Mark

AU - Lake, Stewart

AU - Gilhotra, Jolly

AU - Petrovsky, Nikolai

AU - Hewitt, Alex W

AU - Jenkins, Alicia

AU - Lamoureux, Ecosse L

AU - Gleadle, Jonathan M

AU - Burdon, Kathryn P

AU - Craig, Jamie

PY - 2019/2/24

Y1 - 2019/2/24

N2 - Mitochondrial haplogroups H1, H2 and UK have previously been reported to be associated with proliferative diabetic retinopathy (PDR) in Caucasian patients with diabetes. We aimed to replicate this finding with a larger sample and expand the analysis to include different severities of DR, and diabetic macular edema (DME). Caucasian participants (n = 2935) with either type 1 or type 2 diabetes from the Australian Registry of Advanced Diabetic Retinopathy were enrolled in this study. Twenty-two mitochondrial single nucleotide polymorphisms were genotyped by MassArray and haplogroups reconstructed using Haplogrep. Chi square tests and logistic regressions were used to test associations between haplogroup and DR phenotypes including any DR, non-proliferative DR (NPDR), proliferative DR (PDR) and DME. After stratifying the samples in type 1 and type 2 diabetes groups, and adjusting for sex, age, diabetes duration, concurrent HbA1c and hypertension, neither haplogroups H1, H2, UK, K or JT were associated with any DR, NPDR, PDR or DME.

AB - Mitochondrial haplogroups H1, H2 and UK have previously been reported to be associated with proliferative diabetic retinopathy (PDR) in Caucasian patients with diabetes. We aimed to replicate this finding with a larger sample and expand the analysis to include different severities of DR, and diabetic macular edema (DME). Caucasian participants (n = 2935) with either type 1 or type 2 diabetes from the Australian Registry of Advanced Diabetic Retinopathy were enrolled in this study. Twenty-two mitochondrial single nucleotide polymorphisms were genotyped by MassArray and haplogroups reconstructed using Haplogrep. Chi square tests and logistic regressions were used to test associations between haplogroup and DR phenotypes including any DR, non-proliferative DR (NPDR), proliferative DR (PDR) and DME. After stratifying the samples in type 1 and type 2 diabetes groups, and adjusting for sex, age, diabetes duration, concurrent HbA1c and hypertension, neither haplogroups H1, H2, UK, K or JT were associated with any DR, NPDR, PDR or DME.

KW - Mitochondrial haplogroup

KW - diabetic retinopathy

KW - Australian

KW - British

KW - caucasian sample

UR - http://purl.org/au-research/grants/NHMRC/595918

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U2 - 10.1038/s41598-018-37388-8

DO - 10.1038/s41598-018-37388-8

M3 - Article

SN - 2045-2322

VL - 9

JO - Scientific Reports

JF - Scientific Reports

IS - 1

M1 - 612

ER -

Mitochondrial haplogroups are not associated with diabetic retinopathy in a large Australian and British Caucasian sample.

Abstract

Keywords

UN SDGs

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