Mixture Interpretation (Interpretation of Mixed DNA Profiles With STRs)

Duncan Taylor, Jo Anne Bright, John Buckleton

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Forensic DNA profiling methodology has improved in sensitivity since the introduction of short tandem repeat (STR) analysis in the 1990s. Today, commonly used DNA profiling technology target over 20 STR regions and is able to generate DNA profile data from sub-single-cell DNA amounts. Mixed DNA profiles are often encountered in casework. Methods of profile interpretation have accordingly changed to address the enhanced sensitivity of the methods. In this article we describe the methods of classic and modern profile interpretation and the important characteristics considered during profile interpretation.

Original languageEnglish
Title of host publicationEncyclopedia of Forensic Sciences
Subtitle of host publicationVolume 1-4, Third Edition
EditorsMax M. Houck, Lauren Wilson, Heidi Eldridge, Simon W. Lewis, Kevin Lothridge, Paul Reedy
Place of PublicationAmsterdam
Number of pages11
ISBN (Electronic)9780128236789
Publication statusPublished - 2023


  • Combined probability of inclusion
  • CPI
  • Drop-in
  • Dropout
  • Forensic DNA
  • Hb
  • Heterozygote balance
  • Likelihood Ratio
  • LR
  • Mixture
  • Peak height variance
  • Probabilistic Genotyping
  • Random man not excluded
  • Random match probability
  • RMNE
  • RMP
  • Short tandem repeat
  • Stochastic threshold
  • STR
  • Stutter


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