Mixture Interpretation (Interpretation of Mixed DNA Profiles With STRs)

Duncan Taylor; Jo Anne Bright; John Buckleton

doi:10.1016/B978-0-12-823677-2.00019-2

Mixture Interpretation (Interpretation of Mixed DNA Profiles With STRs)

Duncan Taylor, Jo Anne Bright, John Buckleton

College of Science and Engineering

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Forensic DNA profiling methodology has improved in sensitivity since the introduction of short tandem repeat (STR) analysis in the 1990s. Today, commonly used DNA profiling technology target over 20 STR regions and is able to generate DNA profile data from sub-single-cell DNA amounts. Mixed DNA profiles are often encountered in casework. Methods of profile interpretation have accordingly changed to address the enhanced sensitivity of the methods. In this article we describe the methods of classic and modern profile interpretation and the important characteristics considered during profile interpretation.

Original language	English
Title of host publication	Encyclopedia of Forensic Sciences
Subtitle of host publication	Volume 1-4, Third Edition
Editors	Max M. Houck, Lauren Wilson, Heidi Eldridge, Simon W. Lewis, Kevin Lothridge, Paul Reedy
Place of Publication	Amsterdam
Publisher	Elsevier
Pages	602-612
Number of pages	11
Volume	3
Edition	3rd
ISBN (Electronic)	9780128236789
DOIs	https://doi.org/10.1016/B978-0-12-823677-2.00019-2
Publication status	Published - 2023

Keywords

Combined probability of inclusion
CPI
Drop-in
Dropout
Forensic DNA
Hb
Heterozygote balance
Likelihood Ratio
LR
Mixture
Peak height variance
Probabilistic Genotyping
Random man not excluded
Random match probability
RMNE
RMP
Short tandem repeat
Stochastic threshold
STR
Stutter

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abstract = "Forensic DNA profiling methodology has improved in sensitivity since the introduction of short tandem repeat (STR) analysis in the 1990s. Today, commonly used DNA profiling technology target over 20 STR regions and is able to generate DNA profile data from sub-single-cell DNA amounts. Mixed DNA profiles are often encountered in casework. Methods of profile interpretation have accordingly changed to address the enhanced sensitivity of the methods. In this article we describe the methods of classic and modern profile interpretation and the important characteristics considered during profile interpretation.",

keywords = "Combined probability of inclusion, CPI, Drop-in, Dropout, Forensic DNA, Hb, Heterozygote balance, Likelihood Ratio, LR, Mixture, Peak height variance, Probabilistic Genotyping, Random man not excluded, Random match probability, RMNE, RMP, Short tandem repeat, Stochastic threshold, STR, Stutter",

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Mixture Interpretation (Interpretation of Mixed DNA Profiles With STRs). / Taylor, Duncan; Bright, Jo Anne; Buckleton, John.
Encyclopedia of Forensic Sciences: Volume 1-4, Third Edition. ed. / Max M. Houck; Lauren Wilson; Heidi Eldridge; Simon W. Lewis; Kevin Lothridge; Paul Reedy. Vol. 3 3rd. ed. Amsterdam: Elsevier, 2023. p. 602-612.

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

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AU - Bright, Jo Anne

AU - Buckleton, John

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N2 - Forensic DNA profiling methodology has improved in sensitivity since the introduction of short tandem repeat (STR) analysis in the 1990s. Today, commonly used DNA profiling technology target over 20 STR regions and is able to generate DNA profile data from sub-single-cell DNA amounts. Mixed DNA profiles are often encountered in casework. Methods of profile interpretation have accordingly changed to address the enhanced sensitivity of the methods. In this article we describe the methods of classic and modern profile interpretation and the important characteristics considered during profile interpretation.

AB - Forensic DNA profiling methodology has improved in sensitivity since the introduction of short tandem repeat (STR) analysis in the 1990s. Today, commonly used DNA profiling technology target over 20 STR regions and is able to generate DNA profile data from sub-single-cell DNA amounts. Mixed DNA profiles are often encountered in casework. Methods of profile interpretation have accordingly changed to address the enhanced sensitivity of the methods. In this article we describe the methods of classic and modern profile interpretation and the important characteristics considered during profile interpretation.

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KW - Drop-in

KW - Dropout

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KW - Heterozygote balance

KW - Likelihood Ratio

KW - LR

KW - Mixture

KW - Peak height variance

KW - Probabilistic Genotyping

KW - Random man not excluded

KW - Random match probability

KW - RMNE

KW - RMP

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KW - Stochastic threshold

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KW - Stutter

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BT - Encyclopedia of Forensic Sciences

A2 - Houck, Max M.

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A2 - Eldridge, Heidi

A2 - Lewis, Simon W.

A2 - Lothridge, Kevin

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PB - Elsevier

CY - Amsterdam

ER -

Mixture Interpretation (Interpretation of Mixed DNA Profiles With STRs)

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Keywords

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