MLIP and Its Potential Influence on Key Oncogenic Pathways

Mahmoud N. Hamwi; Engy Elsayed; Hanan Dabash; Amani Abuawad; Noor A. Aweer; Faissal Al Zeir; Shona Pedersen; Layla Al-Mansoori; Patrick G. Burgon

doi:10.3390/cells13131109

MLIP and Its Potential Influence on Key Oncogenic Pathways

Mahmoud N. Hamwi
, Engy Elsayed
, Hanan Dabash
, Amani Abuawad
, Noor A. Aweer
, Faissal Al Zeir
, Shona Pedersen
, Layla Al-Mansoori
, Patrick G. Burgon

Research output: Contribution to journal › Review article › peer-review

1 Citation (Scopus)

6 Downloads (Pure)

Abstract

Muscle-enriched A-type lamin-interacting protein (MLIP) is an emerging protein involved in cellular homeostasis and stress adaptation. Eukaryotic cells regulate various cellular processes, including metabolism, DNA repair, and cell cycle progression, to maintain cellular homeostasis. Disruptions in this homeostasis can lead to diseases such as cancer, characterized by uncontrolled cell growth and division. This review aims to explore for the first time the unique role MLIP may play in cancer development and progression, given its interactions with the PI3K/Akt/mTOR pathway, p53, MAPK9, and FOXO transcription factors, all critical regulators of cellular homeostasis and tumor suppression. We discuss the current understanding of MLIP’s involvement in pro-survival pathways and its potential implications in cancer cells’ metabolic remodeling and dysregulated homeostasis. Additionally, we examine the potential of MLIP as a novel therapeutic target for cancer treatment. This review aims to shed light on MLIP’s potential impact on cancer biology and contribute to developing innovative therapeutic strategies.

Original language	English
Article number	1109
Number of pages	16
Journal	Cells
Volume	13
Issue number	13
DOIs	https://doi.org/10.3390/cells13131109
Publication status	Published - 1 Jul 2024
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Akt
cancer
MLIP
mTOR
PI3 kinase
tumorigenesis

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10.3390/cells13131109Licence: CC BY

Published versionFinal published version, 1.75 MBLicence: CC BY

Cite this

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title = "MLIP and Its Potential Influence on Key Oncogenic Pathways",

abstract = "Muscle-enriched A-type lamin-interacting protein (MLIP) is an emerging protein involved in cellular homeostasis and stress adaptation. Eukaryotic cells regulate various cellular processes, including metabolism, DNA repair, and cell cycle progression, to maintain cellular homeostasis. Disruptions in this homeostasis can lead to diseases such as cancer, characterized by uncontrolled cell growth and division. This review aims to explore for the first time the unique role MLIP may play in cancer development and progression, given its interactions with the PI3K/Akt/mTOR pathway, p53, MAPK9, and FOXO transcription factors, all critical regulators of cellular homeostasis and tumor suppression. We discuss the current understanding of MLIP{\textquoteright}s involvement in pro-survival pathways and its potential implications in cancer cells{\textquoteright} metabolic remodeling and dysregulated homeostasis. Additionally, we examine the potential of MLIP as a novel therapeutic target for cancer treatment. This review aims to shed light on MLIP{\textquoteright}s potential impact on cancer biology and contribute to developing innovative therapeutic strategies.",

keywords = "Akt, cancer, MLIP, mTOR, PI3 kinase, tumorigenesis",

author = "Hamwi, \{Mahmoud N.\} and Engy Elsayed and Hanan Dabash and Amani Abuawad and Aweer, \{Noor A.\} and \{Al Zeir\}, Faissal and Shona Pedersen and Layla Al-Mansoori and Burgon, \{Patrick G.\}",

year = "2024",

month = jul,

day = "1",

doi = "10.3390/cells13131109",

language = "English",

volume = "13",

journal = "Cells",

issn = "2073-4409",

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TY - JOUR

T1 - MLIP and Its Potential Influence on Key Oncogenic Pathways

AU - Hamwi, Mahmoud N.

AU - Elsayed, Engy

AU - Dabash, Hanan

AU - Abuawad, Amani

AU - Aweer, Noor A.

AU - Al Zeir, Faissal

AU - Pedersen, Shona

AU - Al-Mansoori, Layla

AU - Burgon, Patrick G.

PY - 2024/7/1

Y1 - 2024/7/1

N2 - Muscle-enriched A-type lamin-interacting protein (MLIP) is an emerging protein involved in cellular homeostasis and stress adaptation. Eukaryotic cells regulate various cellular processes, including metabolism, DNA repair, and cell cycle progression, to maintain cellular homeostasis. Disruptions in this homeostasis can lead to diseases such as cancer, characterized by uncontrolled cell growth and division. This review aims to explore for the first time the unique role MLIP may play in cancer development and progression, given its interactions with the PI3K/Akt/mTOR pathway, p53, MAPK9, and FOXO transcription factors, all critical regulators of cellular homeostasis and tumor suppression. We discuss the current understanding of MLIP’s involvement in pro-survival pathways and its potential implications in cancer cells’ metabolic remodeling and dysregulated homeostasis. Additionally, we examine the potential of MLIP as a novel therapeutic target for cancer treatment. This review aims to shed light on MLIP’s potential impact on cancer biology and contribute to developing innovative therapeutic strategies.

AB - Muscle-enriched A-type lamin-interacting protein (MLIP) is an emerging protein involved in cellular homeostasis and stress adaptation. Eukaryotic cells regulate various cellular processes, including metabolism, DNA repair, and cell cycle progression, to maintain cellular homeostasis. Disruptions in this homeostasis can lead to diseases such as cancer, characterized by uncontrolled cell growth and division. This review aims to explore for the first time the unique role MLIP may play in cancer development and progression, given its interactions with the PI3K/Akt/mTOR pathway, p53, MAPK9, and FOXO transcription factors, all critical regulators of cellular homeostasis and tumor suppression. We discuss the current understanding of MLIP’s involvement in pro-survival pathways and its potential implications in cancer cells’ metabolic remodeling and dysregulated homeostasis. Additionally, we examine the potential of MLIP as a novel therapeutic target for cancer treatment. This review aims to shed light on MLIP’s potential impact on cancer biology and contribute to developing innovative therapeutic strategies.

KW - Akt

KW - cancer

KW - MLIP

KW - mTOR

KW - PI3 kinase

KW - tumorigenesis

UR - https://www.scopus.com/pages/publications/85198383709

U2 - 10.3390/cells13131109

DO - 10.3390/cells13131109

M3 - Review article

C2 - 38994962

AN - SCOPUS:85198383709

SN - 2073-4409

VL - 13

JO - Cells

JF - Cells

IS - 13

M1 - 1109

ER -

MLIP and Its Potential Influence on Key Oncogenic Pathways

Abstract

UN SDGs

Keywords

Access to Document

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