Chronic intra-colonic linaclotide administration alters glial activation in a mouse model of chronic visceral hypersensitivity

Research output: Contribution to journalMeeting Abstractpeer-review

Abstract

Linaclotide, a guanylate cyclase-C (GC-C) agonist, reduces abdominal pain and improves constipation in patients with irritable bowel syndrome with constipation(IBS-C). We have shown in mice that both chronic oral and intra-colonic administration of linaclotide inhibits colonic nociception with greater efficacy during chronic visceral hyper-sensitivity (CVH) relative to healthy controls. Here we determined the effects of chronic intra-colonic linaclotide administration on glial cells within the dorsal root ganglia (DRG)and spinal cord. This is important as glial cell activation is implicated in the initiation of acute pain and the maintenance of chronic pain.
Original languageEnglish
Article numberMo1146
Pages (from-to)S-803
Number of pages1
JournalGastroenterology
Volume158
Issue number6, Supplement 1
DOIs
Publication statusPublished - May 2020
EventDigestive Disease Week 2020 - McCormick Place, Chicago, United States
Duration: 2 May 20205 May 2020

Keywords

  • Linaclotide
  • Guanylate cyclase C
  • IBS-C
  • intra-colonic administration
  • CVH
  • Chronic visceral pain
  • Glial cell
  • mouse models

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