Chronic intra-colonic linaclotide administration alters glial activation in a mouse model of chronic visceral hypersensitivity

Andrea Harrington; Sonia Garcia-Caraballo; Luke Grundy; Joel Castro; Gerhard Hannig; Stuart Brierley

doi:10.1016/S0016-5085(20)32687-1

Chronic intra-colonic linaclotide administration alters glial activation in a mouse model of chronic visceral hypersensitivity

Andrea Harrington, Sonia Garcia-Caraballo, Luke Grundy, Joel Castro, Gerhard Hannig, Stuart Brierley

College of Medicine and Public Health

Research output: Contribution to journal › Meeting Abstract › peer-review

Abstract

Linaclotide, a guanylate cyclase-C (GC-C) agonist, reduces abdominal pain and improves constipation in patients with irritable bowel syndrome with constipation(IBS-C). We have shown in mice that both chronic oral and intra-colonic administration of linaclotide inhibits colonic nociception with greater efficacy during chronic visceral hyper-sensitivity (CVH) relative to healthy controls. Here we determined the effects of chronic intra-colonic linaclotide administration on glial cells within the dorsal root ganglia (DRG)and spinal cord. This is important as glial cell activation is implicated in the initiation of acute pain and the maintenance of chronic pain.

Original language	English
Article number	Mo1146
Pages (from-to)	S-803
Number of pages	1
Journal	Gastroenterology
Volume	158
Issue number	6, Supplement 1
DOIs	https://doi.org/10.1016/S0016-5085(20)32687-1
Publication status	Published - May 2020
Event	Digestive Disease Week 2020 - McCormick Place, Chicago, United States Duration: 2 May 2020 → 5 May 2020

Keywords

Linaclotide
Guanylate cyclase C
IBS-C
intra-colonic administration
CVH
Chronic visceral pain
Glial cell
mouse models

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title = "Chronic intra-colonic linaclotide administration alters glial activation in a mouse model of chronic visceral hypersensitivity",

abstract = "Linaclotide, a guanylate cyclase-C (GC-C) agonist, reduces abdominal pain and improves constipation in patients with irritable bowel syndrome with constipation(IBS-C). We have shown in mice that both chronic oral and intra-colonic administration of linaclotide inhibits colonic nociception with greater efficacy during chronic visceral hyper-sensitivity (CVH) relative to healthy controls. Here we determined the effects of chronic intra-colonic linaclotide administration on glial cells within the dorsal root ganglia (DRG)and spinal cord. This is important as glial cell activation is implicated in the initiation of acute pain and the maintenance of chronic pain.",

keywords = "Linaclotide, Guanylate cyclase C, IBS-C, intra-colonic administration, CVH, Chronic visceral pain, Glial cell, mouse models",

author = "Andrea Harrington and Sonia Garcia-Caraballo and Luke Grundy and Joel Castro and Gerhard Hannig and Stuart Brierley",

year = "2020",

month = may,

doi = "10.1016/S0016-5085(20)32687-1",

language = "English",

volume = "158",

pages = "S--803",

journal = "Gastroenterology",

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publisher = "W.B. Saunders Co.",

number = "6, Supplement 1",

note = "Digestive Disease Week 2020 ; Conference date: 02-05-2020 Through 05-05-2020",

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TY - JOUR

T1 - Chronic intra-colonic linaclotide administration alters glial activation in a mouse model of chronic visceral hypersensitivity

AU - Harrington, Andrea

AU - Garcia-Caraballo, Sonia

AU - Grundy, Luke

AU - Castro, Joel

AU - Hannig, Gerhard

AU - Brierley, Stuart

PY - 2020/5

Y1 - 2020/5

N2 - Linaclotide, a guanylate cyclase-C (GC-C) agonist, reduces abdominal pain and improves constipation in patients with irritable bowel syndrome with constipation(IBS-C). We have shown in mice that both chronic oral and intra-colonic administration of linaclotide inhibits colonic nociception with greater efficacy during chronic visceral hyper-sensitivity (CVH) relative to healthy controls. Here we determined the effects of chronic intra-colonic linaclotide administration on glial cells within the dorsal root ganglia (DRG)and spinal cord. This is important as glial cell activation is implicated in the initiation of acute pain and the maintenance of chronic pain.

AB - Linaclotide, a guanylate cyclase-C (GC-C) agonist, reduces abdominal pain and improves constipation in patients with irritable bowel syndrome with constipation(IBS-C). We have shown in mice that both chronic oral and intra-colonic administration of linaclotide inhibits colonic nociception with greater efficacy during chronic visceral hyper-sensitivity (CVH) relative to healthy controls. Here we determined the effects of chronic intra-colonic linaclotide administration on glial cells within the dorsal root ganglia (DRG)and spinal cord. This is important as glial cell activation is implicated in the initiation of acute pain and the maintenance of chronic pain.

KW - Linaclotide

KW - Guanylate cyclase C

KW - IBS-C

KW - intra-colonic administration

KW - CVH

KW - Chronic visceral pain

KW - Glial cell

KW - mouse models

U2 - 10.1016/S0016-5085(20)32687-1

DO - 10.1016/S0016-5085(20)32687-1

M3 - Meeting Abstract

SN - 0016-5085

VL - 158

SP - S-803

JO - Gastroenterology

JF - Gastroenterology

IS - 6, Supplement 1

M1 - Mo1146

T2 - Digestive Disease Week 2020

Y2 - 2 May 2020 through 5 May 2020

ER -

Chronic intra-colonic linaclotide administration alters glial activation in a mouse model of chronic visceral hypersensitivity

Abstract

Keywords

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