Mode of action of angiotensin converting enzyme inhibitors

Louise M. Burrell, Paddy A. Phillips, Colin I. Johnston

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The ACE inhibitors have proved to be a significant advance in the therapy of cardiovascular disease. All act in an identical manner by binding to the catalytic site of ACE, but differ in the degree and the length of time of ACE inhibition in different tissues. Although the clinical significance of this is unclear, it raises the exciting possibility of designing ACE inhibitors with tissue selective effects. The mode of action of ACE inhibitors is complex, and further research in this area is necessary particularly with regard to the role of bradykinin. ACE inhibitors can now be regarded as first line therapy for congestive cardiac failure, for patients with left ventricular dysfunction or hypertensive left ventricular hypertrophy and to prevent ventricular remodeling after myocardial infarction when left ventricular function is impaired. ACE inhibitors are the treatment of choice in patients with normotensive or hypertensive diabetic nephropathy. In essential hypertension, ACE inhibitors are at least as effective as other agents in lowering blood pressure and the results of long term clinical trials currently underway will determine whether this translates into a reduction in cardiovascular morbidity and mortality.

Original languageEnglish
Title of host publicationPrinciples of Medical Biology
PublisherElsevier
Pages547-560
Number of pages14
Volume8
ISBN (Electronic)978-1-55938-813-9
DOIs
Publication statusPublished - 1997
Externally publishedYes

Publication series

NamePrinciples of Medical Biology
ISSN (Print)1569-2582

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    Burrell, L. M., Phillips, P. A., & Johnston, C. I. (1997). Mode of action of angiotensin converting enzyme inhibitors. In Principles of Medical Biology (Vol. 8, pp. 547-560). (Principles of Medical Biology). Elsevier. https://doi.org/10.1016/S1569-2582(97)80053-0