Modeling the Influence of Fatty Acid Incorporation on Mesophase Formation in Amphiphilic Therapeutic Delivery Systems

Tu Le, Nhiem Tran, Xavier Mulet, David Alan Winkler

    Research output: Contribution to journalArticle

    6 Citations (Scopus)

    Abstract

    Dispersed amphiphile-fatty acid systems are of great interest in drug delivery and gene therapies because of their potential for triggered release of their payload. The mesophase behavior of these systems is extremely complex and is affected by environmental factors such as drug loading, percentage and nature of incorporated fatty acids, temperature, pH, and so forth. It is important to study phase behavior of amphiphilic materials as the mesophases directly influence the release rate of the incorporated drugs. We describe a robust machine learning method for predicting the phase behavior of these systems. We have developed models for each mesophase that simultaneous and reliably model the effects of amphiphile and fatty acid structure, concentration, and temperature and that make accurate predictions of these mesophases for conditions not used to train the models.

    Original languageEnglish
    Pages (from-to)996-1003
    Number of pages8
    JournalMolecular Pharmaceutics
    Volume13
    Issue number3
    DOIs
    Publication statusPublished - 2016

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