Modic (Endplate) Changes in the Lumbar Spine: a preliminary Report on Bone Microarchitecture and Remodeling

Egon Perilli, John Ooi, Lena Truong, Ian Parkinson, Sladjana Jovcic, Orso Osti, Nick Fazzalari

Research output: Contribution to conferencePosterpeer-review


This is a preliminary report on the bone microarchitecture and remodeling characteristics of Modic changes in adult human lumbar vertebrae of individuals undergoing spinal surgery for degenerative disease. Modic et al. in 1988 first described characteristic MRI changes in the vertebral body bone marrow and endplates, adjacent to degenerating intervertebral (iv) discs. Depending on the changes in T1 and T2 MRI signals, three types of lesions were identified: Type I lesions (low T1 and high T2 signal) are thought to be clinically active, due to increased blood flow within the bone. Type II lesions (high T1 and T2 signals) possibly reflect fatty degeneration of the bone marrow. Type III lesions (low T1 and T2 signals) are assumed to correlate with sub-chondral bone sclerosis / thickening [1]. Their occurrence appears to increase with age [2] and is associated with low back pain.
Original languageEnglish
Number of pages1
Publication statusPublished - 2010
Externally publishedYes
EventOrthopaedic Research Society (ORS) Annual Meeting -, New Orleans, United States
Duration: 6 Mar 20109 Mar 2010
Conference number: 56


ConferenceOrthopaedic Research Society (ORS) Annual Meeting
Country/TerritoryUnited States
CityNew Orleans
OtherThe ORS Annual Meeting continues to be an extraordinary conference enabling members and non-members to bring new scientific discoveries to a forum for open discussion and debate. There is no other society that comprehensively integrates engineering and biological research on all cells, tissues and organs of the musculoskeletal system in an environment in which these new discoveries can be translated to the clinical environment. This is the most important activity of our Society. The Program Committee, Topic Chairs, and more than 200 volunteer abstract reviewers are working very hard to put together a program that will help to bring us up to date on the best, late-breaking research in our field.


  • micro-CT
  • Modic changes


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