Modic (Endplate) Changes in the Lumbar Spine: a preliminary Report on Bone Microarchitecture and Remodeling

Egon Perilli; John Ooi; Lena Truong; Ian Parkinson; Sladjana Jovcic; Orso Osti; Nick Fazzalari

Modic (Endplate) Changes in the Lumbar Spine: a preliminary Report on Bone Microarchitecture and Remodeling

Egon Perilli, John Ooi, Lena Truong, Ian Parkinson, Sladjana Jovcic, Orso Osti, Nick Fazzalari

Research output: Contribution to conference › Poster › peer-review

Abstract

This is a preliminary report on the bone microarchitecture and remodeling characteristics of Modic changes in adult human lumbar vertebrae of individuals undergoing spinal surgery for degenerative disease. Modic et al. in 1988 first described characteristic MRI changes in the vertebral body bone marrow and endplates, adjacent to degenerating intervertebral (iv) discs. Depending on the changes in T1 and T2 MRI signals, three types of lesions were identified: Type I lesions (low T1 and high T2 signal) are thought to be clinically active, due to increased blood flow within the bone. Type II lesions (high T1 and T2 signals) possibly reflect fatty degeneration of the bone marrow. Type III lesions (low T1 and T2 signals) are assumed to correlate with sub-chondral bone sclerosis / thickening [1]. Their occurrence appears to increase with age [2] and is associated with low back pain.

Original language	English
Number of pages	1
Publication status	Published - 2010
Externally published	Yes
Event	Orthopaedic Research Society (ORS) Annual Meeting - https://www.ors.org/abstract-search/, New Orleans, United States Duration: 6 Mar 2010 → 9 Mar 2010 Conference number: 56

Conference

Conference	Orthopaedic Research Society (ORS) Annual Meeting
Country/Territory	United States
City	New Orleans
Period	6/03/10 → 9/03/10
Other	The ORS Annual Meeting continues to be an extraordinary conference enabling members and non-members to bring new scientific discoveries to a forum for open discussion and debate. There is no other society that comprehensively integrates engineering and biological research on all cells, tissues and organs of the musculoskeletal system in an environment in which these new discoveries can be translated to the clinical environment. This is the most important activity of our Society. The Program Committee, Topic Chairs, and more than 200 volunteer abstract reviewers are working very hard to put together a program that will help to bring us up to date on the best, late-breaking research in our field.

Keywords

micro-CT
Modic changes

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Cite this

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title = "Modic (Endplate) Changes in the Lumbar Spine: a preliminary Report on Bone Microarchitecture and Remodeling",

abstract = "This is a preliminary report on the bone microarchitecture and remodeling characteristics of Modic changes in adult human lumbar vertebrae of individuals undergoing spinal surgery for degenerative disease. Modic et al. in 1988 first described characteristic MRI changes in the vertebral body bone marrow and endplates, adjacent to degenerating intervertebral (iv) discs. Depending on the changes in T1 and T2 MRI signals, three types of lesions were identified: Type I lesions (low T1 and high T2 signal) are thought to be clinically active, due to increased blood flow within the bone. Type II lesions (high T1 and T2 signals) possibly reflect fatty degeneration of the bone marrow. Type III lesions (low T1 and T2 signals) are assumed to correlate with sub-chondral bone sclerosis / thickening [1]. Their occurrence appears to increase with age [2] and is associated with low back pain.",

keywords = "micro-CT, Modic changes",

author = "Egon Perilli and John Ooi and Lena Truong and Ian Parkinson and Sladjana Jovcic and Orso Osti and Nick Fazzalari",

year = "2010",

language = "English",

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T1 - Modic (Endplate) Changes in the Lumbar Spine

T2 - Orthopaedic Research Society (ORS) Annual Meeting

AU - Perilli, Egon

AU - Ooi, John

AU - Truong, Lena

AU - Parkinson, Ian

AU - Jovcic, Sladjana

AU - Osti, Orso

AU - Fazzalari, Nick

N1 - Conference code: 56

PY - 2010

Y1 - 2010

N2 - This is a preliminary report on the bone microarchitecture and remodeling characteristics of Modic changes in adult human lumbar vertebrae of individuals undergoing spinal surgery for degenerative disease. Modic et al. in 1988 first described characteristic MRI changes in the vertebral body bone marrow and endplates, adjacent to degenerating intervertebral (iv) discs. Depending on the changes in T1 and T2 MRI signals, three types of lesions were identified: Type I lesions (low T1 and high T2 signal) are thought to be clinically active, due to increased blood flow within the bone. Type II lesions (high T1 and T2 signals) possibly reflect fatty degeneration of the bone marrow. Type III lesions (low T1 and T2 signals) are assumed to correlate with sub-chondral bone sclerosis / thickening [1]. Their occurrence appears to increase with age [2] and is associated with low back pain.

AB - This is a preliminary report on the bone microarchitecture and remodeling characteristics of Modic changes in adult human lumbar vertebrae of individuals undergoing spinal surgery for degenerative disease. Modic et al. in 1988 first described characteristic MRI changes in the vertebral body bone marrow and endplates, adjacent to degenerating intervertebral (iv) discs. Depending on the changes in T1 and T2 MRI signals, three types of lesions were identified: Type I lesions (low T1 and high T2 signal) are thought to be clinically active, due to increased blood flow within the bone. Type II lesions (high T1 and T2 signals) possibly reflect fatty degeneration of the bone marrow. Type III lesions (low T1 and T2 signals) are assumed to correlate with sub-chondral bone sclerosis / thickening [1]. Their occurrence appears to increase with age [2] and is associated with low back pain.

KW - micro-CT

KW - Modic changes

M3 - Poster

Y2 - 6 March 2010 through 9 March 2010

ER -

Modic (Endplate) Changes in the Lumbar Spine: a preliminary Report on Bone Microarchitecture and Remodeling

Abstract

Conference

Keywords

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