TY - JOUR
T1 - Modified green synthesis of Fe3O4@SiO2 nanoparticles for pH responsive drug release
AU - Cai, Wanling
AU - Guo, Mengyu
AU - Weng, Xiulan
AU - Zhang, Wei
AU - Owens, Gary
AU - Chen, Zuliang
PY - 2020/7
Y1 - 2020/7
N2 - A magnetic field activated drug delivery and pH-sensitive controlled drug release system based on carboxyl-modified green synthesized Fe3O4@SiO2 (Fe3O4@SiO2-Glu) nanoparticles was established. Doxorubicin hydrochloride (DOX), as a drug model, was adsorbed onto the Fe3O4@SiO2-Glu nanoparticles' surface, where the observed drug loading capacity of 34.6 mg/g was attributed to electrostatic interaction between -COO– on the surface of Fe3O4@SiO2-Glu and -NH3 + of DOX. The structure, morphology and physiochemical properties of Fe3O4@SiO2-Glu were characterized via TEM, FTIR, XRD, N2 adsorption/desorption isotherms, and Zeta potential measurements. The green synthesized Fe3O4@SiO2-Glu nanoparticles exhibited multilayer architecture with a BET surface area of 79.9 m2/g and a magnetization saturation of 25.9 emu/g. Drug release experiments indicated that DOX was pH trigger released with 60.8% released within 72 h at pH 3.5. This system has important potential implications for the design of more effective and stable magnetic Fe3O4@SiO2-Glu materials as drug carriers for targeted and controlled drug release.
AB - A magnetic field activated drug delivery and pH-sensitive controlled drug release system based on carboxyl-modified green synthesized Fe3O4@SiO2 (Fe3O4@SiO2-Glu) nanoparticles was established. Doxorubicin hydrochloride (DOX), as a drug model, was adsorbed onto the Fe3O4@SiO2-Glu nanoparticles' surface, where the observed drug loading capacity of 34.6 mg/g was attributed to electrostatic interaction between -COO– on the surface of Fe3O4@SiO2-Glu and -NH3 + of DOX. The structure, morphology and physiochemical properties of Fe3O4@SiO2-Glu were characterized via TEM, FTIR, XRD, N2 adsorption/desorption isotherms, and Zeta potential measurements. The green synthesized Fe3O4@SiO2-Glu nanoparticles exhibited multilayer architecture with a BET surface area of 79.9 m2/g and a magnetization saturation of 25.9 emu/g. Drug release experiments indicated that DOX was pH trigger released with 60.8% released within 72 h at pH 3.5. This system has important potential implications for the design of more effective and stable magnetic Fe3O4@SiO2-Glu materials as drug carriers for targeted and controlled drug release.
KW - Doxorubicin hydrochloride (DOX)
KW - Drug release
KW - Modified FeO@SiO
KW - pH-dependent
UR - http://www.scopus.com/inward/record.url?scp=85082537235&partnerID=8YFLogxK
U2 - 10.1016/j.msec.2020.110900
DO - 10.1016/j.msec.2020.110900
M3 - Article
C2 - 32409056
AN - SCOPUS:85082537235
SN - 0928-4931
VL - 112
JO - Materials Science and Engineering C
JF - Materials Science and Engineering C
M1 - 110900
ER -