Modulation of the immune system by UV radiation: More than just the effects of vitamin D?

Prudence Hart, S Gorman, John Finlay-Jones

    Research output: Contribution to journalReview articlepeer-review

    309 Citations (Scopus)

    Abstract

    Humans obtain most of their vitamin D through the exposure of skin to sunlight. The immunoregulatory properties of vitamin D have been demonstrated in studies showing that vitamin D deficiency is associated with poor immune function and increased disease susceptibility. The benefits of moderate ultraviolet (UV) radiation exposure and the positive latitude gradients observed for some immune-mediated diseases may therefore reflect the activities of UV-induced vitamin D. Alternatively, other mediators that are induced by UV radiation may be more important for UV-mediated immunomodulation. Here, we compare and contrast the effects of UV radiation and vitamin D on immune function in immunopathological diseases, such as psoriasis, multiple sclerosis and asthma, and during infection.

    Original languageEnglish
    Pages (from-to)584-596
    Number of pages13
    JournalNATURE REVIEWS IMMUNOLOGY
    Volume11
    Issue number9
    DOIs
    Publication statusPublished - Sep 2011

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