Modulation of the renin-angiotensin system by atrial natriuretic peptide

C. I. Johnston, P. A. Phillips, L. Arnolda, V. Mooser

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Many hormonal systems are involved in salt homeostasis and blood pressure control, including the rennin-angiotensin-aldosterone system, the kallikrein-kinin system, and atrial and brain natriuretic peptides. Many of these hormonal peptides have actions both in the central nervous system and the periphery that are complementary. There is also increasing evidence that many of them may act as both circulating endocrine systems as well as local paracrine automne systems. The atrial natriuretic peptides may be viewed as endogenous inhibitors of the renin-angiotensin system. Angiotensin-converting enzyme (ACE) and renin inhibitors have provided important information on the role of the renin-angiotensin system in physiological and pathophysiologic states. The development of specific atriopeptidase inhibitors, kinin antagonists, and kallikrein inhibitors offer the same promise for these systems.

Original languageEnglish
Pages (from-to)S43-S46
Number of pages4
JournalJournal of Cardiovascular Pharmacology
Issue numberSupplement 7
Publication statusPublished - 1990
Externally publishedYes


  • aldosterone system
  • Atrial natriuretic peptide
  • Blood pressure
  • Kallikrein-kinin system
  • Renin-angiotensin
  • Salt


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