Molecular and Biochemical Aspects of the Retina on Refraction

Ranjay Chakraborty, Machelle Pardue

    Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

    33 Citations (Scopus)


    Mutant mouse models with specific visual pathway defects offer an advantage to comprehensively investigate the role of specific pathways/neurons involved in refractive development. In this review, we will focus on recent studies using mouse models that have provided insight into retinal pathways and neurotransmitters controlling refractive development. Specifically, we will examine the contributions of rod and cone photoreceptors and the ON and OFF retinal pathways to visually driven eye growth with emphasis on dopaminergic mechanisms.

    Original languageEnglish
    Title of host publicationMolecular Biology of Eye Disease
    EditorsJohn M. Nickerson, J. Fielding Hejtmancik
    Number of pages19
    ISBN (Print)9780128010594
    Publication statusPublished - 2015

    Publication series

    NameProgress in Molecular Biology and Translational Science
    ISSN (Print)1877-1173
    ISSN (Electronic)1878-0814


    • Form deprivation
    • Mice
    • Myopia
    • OFF bipolar cells
    • ON bipolar cells
    • Photoreceptors
    • Refraction


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