Molecular approaches to enhance surveillance of gonococcal antimicrobial resistance

Namraj Goire, Monica Lahra, Marcus Chen, Basil Donovan, Christopher Fairley, Rebecca Guy, John Kaldor, David Regan, James Ward, Michael Nissen, Theo Sloots, David Whiley

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

The best available data indicate that the world is heading towards a pandemic of extensively drug-resistant Neisseria gonorrhoeae. At the same time, clinical microbiology laboratories have moved away from using culture-based methods to diagnose gonorrhoea, thus undermining our ability to detect antimicrobial resistance (AMR) using current technologies. In this Opinion article, we discuss the problem of N. gonorrhoeae AMR, particularly emerging resistance to the cephalosporin ceftriaxone, outline current concerns about the surveillance of N. gonorrhoeae AMR and propose the use of molecular methods on a large scale to systematically enhance surveillance.

Original languageEnglish
Pages (from-to)223-229
Number of pages7
JournalNATURE REVIEWS MICROBIOLOGY
Volume12
Issue number3
DOIs
Publication statusPublished - 2014

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    Goire, N., Lahra, M., Chen, M., Donovan, B., Fairley, C., Guy, R., Kaldor, J., Regan, D., Ward, J., Nissen, M., Sloots, T., & Whiley, D. (2014). Molecular approaches to enhance surveillance of gonococcal antimicrobial resistance. NATURE REVIEWS MICROBIOLOGY, 12(3), 223-229. https://doi.org/10.1038/nrmicro3217