Molecular approaches to enhance surveillance of gonococcal antimicrobial resistance

Namraj Goire; Monica Lahra; Marcus Chen; Basil Donovan; Christopher Fairley; Rebecca Guy; John Kaldor; David Regan; James Ward; Michael Nissen; Theo Sloots; David Whiley

doi:10.1038/nrmicro3217

Molecular approaches to enhance surveillance of gonococcal antimicrobial resistance

Namraj Goire, Monica Lahra, Marcus Chen, Basil Donovan, Christopher Fairley, Rebecca Guy, John Kaldor, David Regan, James Ward, Michael Nissen, Theo Sloots, David Whiley

College of Medicine and Public Health

Research output: Contribution to journal › Review article › peer-review

90 Citations (Scopus)

Abstract

The best available data indicate that the world is heading towards a pandemic of extensively drug-resistant Neisseria gonorrhoeae. At the same time, clinical microbiology laboratories have moved away from using culture-based methods to diagnose gonorrhoea, thus undermining our ability to detect antimicrobial resistance (AMR) using current technologies. In this Opinion article, we discuss the problem of N. gonorrhoeae AMR, particularly emerging resistance to the cephalosporin ceftriaxone, outline current concerns about the surveillance of N. gonorrhoeae AMR and propose the use of molecular methods on a large scale to systematically enhance surveillance.

Original language	English
Pages (from-to)	223-229
Number of pages	7
Journal	NATURE REVIEWS MICROBIOLOGY
Volume	12
Issue number	3
DOIs	https://doi.org/10.1038/nrmicro3217
Publication status	Published - Mar 2014

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title = "Molecular approaches to enhance surveillance of gonococcal antimicrobial resistance",

abstract = "The best available data indicate that the world is heading towards a pandemic of extensively drug-resistant Neisseria gonorrhoeae. At the same time, clinical microbiology laboratories have moved away from using culture-based methods to diagnose gonorrhoea, thus undermining our ability to detect antimicrobial resistance (AMR) using current technologies. In this Opinion article, we discuss the problem of N. gonorrhoeae AMR, particularly emerging resistance to the cephalosporin ceftriaxone, outline current concerns about the surveillance of N. gonorrhoeae AMR and propose the use of molecular methods on a large scale to systematically enhance surveillance.",

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T1 - Molecular approaches to enhance surveillance of gonococcal antimicrobial resistance

AU - Goire, Namraj

AU - Lahra, Monica

AU - Chen, Marcus

AU - Donovan, Basil

AU - Fairley, Christopher

AU - Guy, Rebecca

AU - Kaldor, John

AU - Regan, David

AU - Ward, James

AU - Nissen, Michael

AU - Sloots, Theo

AU - Whiley, David

PY - 2014/3

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N2 - The best available data indicate that the world is heading towards a pandemic of extensively drug-resistant Neisseria gonorrhoeae. At the same time, clinical microbiology laboratories have moved away from using culture-based methods to diagnose gonorrhoea, thus undermining our ability to detect antimicrobial resistance (AMR) using current technologies. In this Opinion article, we discuss the problem of N. gonorrhoeae AMR, particularly emerging resistance to the cephalosporin ceftriaxone, outline current concerns about the surveillance of N. gonorrhoeae AMR and propose the use of molecular methods on a large scale to systematically enhance surveillance.

AB - The best available data indicate that the world is heading towards a pandemic of extensively drug-resistant Neisseria gonorrhoeae. At the same time, clinical microbiology laboratories have moved away from using culture-based methods to diagnose gonorrhoea, thus undermining our ability to detect antimicrobial resistance (AMR) using current technologies. In this Opinion article, we discuss the problem of N. gonorrhoeae AMR, particularly emerging resistance to the cephalosporin ceftriaxone, outline current concerns about the surveillance of N. gonorrhoeae AMR and propose the use of molecular methods on a large scale to systematically enhance surveillance.

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M3 - Review article

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JO - NATURE REVIEWS MICROBIOLOGY

JF - NATURE REVIEWS MICROBIOLOGY

IS - 3

ER -

Molecular approaches to enhance surveillance of gonococcal antimicrobial resistance

Abstract

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