Molecular Characterization of Testicular Mesothelioma and the Role of Asbestos as a Causative Factor

Ashleigh Jean Hocking; Elaine May Thomas; Sarita Prabhakaran; Alexandra Jolley; Susan Lesley Woods; Matthew J. Soeberg; Sonja Klebe

doi:10.5858/arpa.2022-0283-OA

Molecular Characterization of Testicular Mesothelioma and the Role of Asbestos as a Causative Factor

Ashleigh Jean Hocking, Elaine May Thomas, Sarita Prabhakaran, Alexandra Jolley, Susan Lesley Woods, Matthew J. Soeberg, Sonja Klebe

College of Medicine and Public Health

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

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Abstract

CONTEXT.—: Mesothelioma of the tunica vaginalis testis (TVT) is an extremely rare form of mesothelioma.

OBJECTIVE.—: To compare the clinical and molecular characteristics of mesothelioma of the TVT with those of mesothelioma at other more common sites, including the relationship with exposure to asbestos.

DESIGN.—: We present clinical and pathological data for 9 cases of primary TVT mesothelioma. We performed whole-genome sequencing on 3 cases for the first time.

RESULTS.—: The majority (7 of 9 cases) of TVT mesotheliomas were epithelioid, with the remaining 2 cases showing biphasic morphology. Morphology and immunohistochemical profiles were indistinguishable from mesothelioma elsewhere. Asbestos exposure was documented for 7 of the 9 cases, with no information for 2 cases. The 3 TVT mesothelioma cases that underwent whole-genome sequencing displayed a mutational profile similar to that of mesothelioma at other sites, including NF2 and TP53 mutations.

CONCLUSIONS.—: The clinical and molecular profile of TVT mesothelioma is similar to that of mesothelioma elsewhere.

Original language	English
Pages (from-to)	1446-1450
Number of pages	5
Journal	Archives of pathology & laboratory medicine
Volume	147
Issue number	12
DOIs	https://doi.org/10.5858/arpa.2022-0283-OA
Publication status	Published - Dec 2023

Bibliographical note

Publisher Copyright:
© 2023 College of American Pathologists.

Keywords

Asbestos
Mesothelioma
Testicular Neoplasms

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10.5858/arpa.2022-0283-OALicence: CC BY

Final published versionFinal published version, 593 KBLicence: CC BY

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title = "Molecular Characterization of Testicular Mesothelioma and the Role of Asbestos as a Causative Factor",

abstract = "CONTEXT.—: Mesothelioma of the tunica vaginalis testis (TVT) is an extremely rare form of mesothelioma. OBJECTIVE.—: To compare the clinical and molecular characteristics of mesothelioma of the TVT with those of mesothelioma at other more common sites, including the relationship with exposure to asbestos. DESIGN.—: We present clinical and pathological data for 9 cases of primary TVT mesothelioma. We performed whole-genome sequencing on 3 cases for the first time. RESULTS.—: The majority (7 of 9 cases) of TVT mesotheliomas were epithelioid, with the remaining 2 cases showing biphasic morphology. Morphology and immunohistochemical profiles were indistinguishable from mesothelioma elsewhere. Asbestos exposure was documented for 7 of the 9 cases, with no information for 2 cases. The 3 TVT mesothelioma cases that underwent whole-genome sequencing displayed a mutational profile similar to that of mesothelioma at other sites, including NF2 and TP53 mutations. CONCLUSIONS.—: The clinical and molecular profile of TVT mesothelioma is similar to that of mesothelioma elsewhere.",

keywords = "Asbestos, Mesothelioma, Testicular Neoplasms",

author = "Hocking, {Ashleigh Jean} and Thomas, {Elaine May} and Sarita Prabhakaran and Alexandra Jolley and Woods, {Susan Lesley} and Soeberg, {Matthew J.} and Sonja Klebe",

note = "Publisher Copyright: {\textcopyright} 2023 College of American Pathologists.",

year = "2023",

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doi = "10.5858/arpa.2022-0283-OA",

language = "English",

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AU - Thomas, Elaine May

AU - Prabhakaran, Sarita

AU - Jolley, Alexandra

AU - Woods, Susan Lesley

AU - Soeberg, Matthew J.

AU - Klebe, Sonja

PY - 2023/12

Y1 - 2023/12

N2 - CONTEXT.—: Mesothelioma of the tunica vaginalis testis (TVT) is an extremely rare form of mesothelioma. OBJECTIVE.—: To compare the clinical and molecular characteristics of mesothelioma of the TVT with those of mesothelioma at other more common sites, including the relationship with exposure to asbestos. DESIGN.—: We present clinical and pathological data for 9 cases of primary TVT mesothelioma. We performed whole-genome sequencing on 3 cases for the first time. RESULTS.—: The majority (7 of 9 cases) of TVT mesotheliomas were epithelioid, with the remaining 2 cases showing biphasic morphology. Morphology and immunohistochemical profiles were indistinguishable from mesothelioma elsewhere. Asbestos exposure was documented for 7 of the 9 cases, with no information for 2 cases. The 3 TVT mesothelioma cases that underwent whole-genome sequencing displayed a mutational profile similar to that of mesothelioma at other sites, including NF2 and TP53 mutations. CONCLUSIONS.—: The clinical and molecular profile of TVT mesothelioma is similar to that of mesothelioma elsewhere.

AB - CONTEXT.—: Mesothelioma of the tunica vaginalis testis (TVT) is an extremely rare form of mesothelioma. OBJECTIVE.—: To compare the clinical and molecular characteristics of mesothelioma of the TVT with those of mesothelioma at other more common sites, including the relationship with exposure to asbestos. DESIGN.—: We present clinical and pathological data for 9 cases of primary TVT mesothelioma. We performed whole-genome sequencing on 3 cases for the first time. RESULTS.—: The majority (7 of 9 cases) of TVT mesotheliomas were epithelioid, with the remaining 2 cases showing biphasic morphology. Morphology and immunohistochemical profiles were indistinguishable from mesothelioma elsewhere. Asbestos exposure was documented for 7 of the 9 cases, with no information for 2 cases. The 3 TVT mesothelioma cases that underwent whole-genome sequencing displayed a mutational profile similar to that of mesothelioma at other sites, including NF2 and TP53 mutations. CONCLUSIONS.—: The clinical and molecular profile of TVT mesothelioma is similar to that of mesothelioma elsewhere.

KW - Asbestos

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KW - Testicular Neoplasms

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Molecular Characterization of Testicular Mesothelioma and the Role of Asbestos as a Causative Factor

Abstract

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