Molecular Fragmentation as a Strategy to Access Hyperpolarized Compounds from Para-Hydrogen

Hyperpolarization significantly increases the detectability of molecules in magnetic resonance spectroscopy and imaging. Beyond recent advancements in hardware and catalyst design, this article discusses harnessing the inherent chemical reactivity of hyperpolarization target molecules as a strategy to expand the scope and versatility of para-hydrogen-based methods. Various fragmentation reactions are considered for their potential to generate otherwise inaccessible hyperpolarized species, thereby broadening potential applications.