Molecular insights into hypoxic burden physiopathology in OSA: A proteomic perspective

Lucia Pinilla; Krish Dodani; Iván Benitez; Neda Esmaeli; Esther Gracia-Lavedan; Gerard Torres; Olga Minguez; Dolores Martínez; Miguel Ángel Martínez-García; Jorge Abad; Maria Jose Masdeu; Olga Mediano; Carmen Múñoz; Valentín Cabriada; Joaquín Duran-Cantolla; Mercedes Mayos; Ramón Coloma; Josep Maria Montserrat; Mónica de la Peña; Irene Cano-Pumarega; Ferran Barbé; Ali Azarbarzin; Manuel Sanchez-de-la-Torre

doi:10.1183/13993003.congress-2024.PA2693

Molecular insights into hypoxic burden physiopathology in OSA: A proteomic perspective

Lucia Pinilla
, Krish Dodani
, Iván Benitez
, Neda Esmaeli
, Esther Gracia-Lavedan
, Gerard Torres
, Olga Minguez
, Dolores Martínez
, Miguel Ángel Martínez-García
, Jorge Abad
, Maria Jose Masdeu
, Olga Mediano
, Carmen Múñoz
, Valentín Cabriada
, Joaquín Duran-Cantolla
, Mercedes Mayos
, Ramón Coloma
, Josep Maria Montserrat
, Mónica de la Peña
, Irene Cano-Pumarega

Ferran Barbé, Ali Azarbarzin, Manuel Sanchez-de-la-Torre

Research output: Contribution to journal › Meeting Abstract › peer-review

Abstract

Background: Hypoxic burden (HB) has emerged as a strong indicator of cardiovascular (CV) risk and response to treatment in obstructive sleep apnea (OSA). The molecular mechanisms and pathways that relate HB to CV disease have not been investigated.

Original language	English
Number of pages	3
Journal	European Respiratory Journal
Volume	64
Issue number	Supplement 68
DOIs	https://doi.org/10.1183/13993003.congress-2024.PA2693
Publication status	Published - 30 Oct 2024
Externally published	Yes
Event	ERS Congress 2024 - Vienna, Austria Duration: 7 Sept 2024 → 11 Sept 2024

Keywords

Hypoxic burden
cardiovascular risk
obstructive sleep apnea (OSA)
proteomic profile

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10.1183/13993003.congress-2024.PA2693Licence: In Copyright

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Pinilla, L., Dodani, K., Benitez, I., Esmaeli, N., Gracia-Lavedan, E., Torres, G., Minguez, O., Martínez, D., Martínez-García, M. Á., Abad, J., Masdeu, M. J., Mediano, O., Múñoz, C., Cabriada, V., Duran-Cantolla, J., Mayos, M., Coloma, R., Montserrat, J. M., la Peña, M. D., ... Sanchez-de-la-Torre, M. (2024). Molecular insights into hypoxic burden physiopathology in OSA: A proteomic perspective. European Respiratory Journal, 64(Supplement 68). https://doi.org/10.1183/13993003.congress-2024.PA2693

@article{0e64729bb7264692a565087ef211f8dd,

title = "Molecular insights into hypoxic burden physiopathology in OSA: A proteomic perspective",

abstract = "Background: Hypoxic burden (HB) has emerged as a strong indicator of cardiovascular (CV) risk and response to treatment in obstructive sleep apnea (OSA). The molecular mechanisms and pathways that relate HB to CV disease have not been investigated. ",

keywords = "Hypoxic burden, cardiovascular risk, obstructive sleep apnea (OSA), proteomic profile",

author = "Lucia Pinilla and Krish Dodani and Iv{\'a}n Benitez and Neda Esmaeli and Esther Gracia-Lavedan and Gerard Torres and Olga Minguez and Dolores Mart{\'i}nez and Mart{\'i}nez-Garc{\'i}a, \{Miguel {\'A}ngel\} and Jorge Abad and Masdeu, \{Maria Jose\} and Olga Mediano and Carmen M{\'u}{\~n}oz and Valent{\'i}n Cabriada and Joaqu{\'i}n Duran-Cantolla and Mercedes Mayos and Ram{\'o}n Coloma and Montserrat, \{Josep Maria\} and \{la Pe{\~n}a\}, \{M{\'o}nica de\} and Irene Cano-Pumarega and Ferran Barb{\'e} and Ali Azarbarzin and Manuel Sanchez-de-la-Torre",

year = "2024",

month = oct,

day = "30",

doi = "10.1183/13993003.congress-2024.PA2693",

language = "English",

volume = "64",

journal = "European Respiratory Journal",

issn = "1399-3003",

publisher = "European Respiratory Society",

number = "Supplement 68",

note = "ERS Congress 2024 ; Conference date: 07-09-2024 Through 11-09-2024",

}

Pinilla, L, Dodani, K, Benitez, I, Esmaeli, N, Gracia-Lavedan, E, Torres, G, Minguez, O, Martínez, D, Martínez-García, MÁ, Abad, J, Masdeu, MJ, Mediano, O, Múñoz, C, Cabriada, V, Duran-Cantolla, J, Mayos, M, Coloma, R, Montserrat, JM, la Peña, MD, Cano-Pumarega, I, Barbé, F, Azarbarzin, A & Sanchez-de-la-Torre, M 2024, 'Molecular insights into hypoxic burden physiopathology in OSA: A proteomic perspective', European Respiratory Journal, vol. 64, no. Supplement 68. https://doi.org/10.1183/13993003.congress-2024.PA2693

TY - JOUR

T1 - Molecular insights into hypoxic burden physiopathology in OSA

T2 - ERS Congress 2024

AU - Pinilla, Lucia

AU - Dodani, Krish

AU - Benitez, Iván

AU - Esmaeli, Neda

AU - Gracia-Lavedan, Esther

AU - Torres, Gerard

AU - Minguez, Olga

AU - Martínez, Dolores

AU - Martínez-García, Miguel Ángel

AU - Abad, Jorge

AU - Masdeu, Maria Jose

AU - Mediano, Olga

AU - Múñoz, Carmen

AU - Cabriada, Valentín

AU - Duran-Cantolla, Joaquín

AU - Mayos, Mercedes

AU - Coloma, Ramón

AU - Montserrat, Josep Maria

AU - la Peña, Mónica de

AU - Cano-Pumarega, Irene

AU - Barbé, Ferran

AU - Azarbarzin, Ali

AU - Sanchez-de-la-Torre, Manuel

PY - 2024/10/30

Y1 - 2024/10/30

N2 - Background: Hypoxic burden (HB) has emerged as a strong indicator of cardiovascular (CV) risk and response to treatment in obstructive sleep apnea (OSA). The molecular mechanisms and pathways that relate HB to CV disease have not been investigated.

AB - Background: Hypoxic burden (HB) has emerged as a strong indicator of cardiovascular (CV) risk and response to treatment in obstructive sleep apnea (OSA). The molecular mechanisms and pathways that relate HB to CV disease have not been investigated.

KW - Hypoxic burden

KW - cardiovascular risk

KW - obstructive sleep apnea (OSA)

KW - proteomic profile

U2 - 10.1183/13993003.congress-2024.PA2693

DO - 10.1183/13993003.congress-2024.PA2693

M3 - Meeting Abstract

SN - 1399-3003

VL - 64

JO - European Respiratory Journal

JF - European Respiratory Journal

IS - Supplement 68

Y2 - 7 September 2024 through 11 September 2024

ER -

Molecular insights into hypoxic burden physiopathology in OSA: A proteomic perspective

Abstract

Keywords

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