Monoamine metabolite concentrations in lumbar cerebrospinal fluid of patients with histologically verified Alzheimer's dementia

A. M. Palmer, N. R. Sims, D. M. Bowen, D. Neary, J. Palo, J. Wikstrom, A. N. Davison

Research output: Contribution to journalArticlepeer-review

68 Citations (Scopus)

Abstract

Concentrations of 3-methoxy-4-hydroxyphenylglycol (MHPG), 5-hydroxy indoleacetic acid (5-HIAA) and homovanillic acid (HVA) were determined in lumbar cerebrospinal fluid (CSF) from control subjects and patients of both presenile and senile age with histologically verified Alzheimer's dementia. CSF HVA increased with age in control but not in Alzheimer patients. HVA and 5-HIAA in the CSF of presenile Alzheimer patients was lower than that of age matched control subjects.

Original languageEnglish
Pages (from-to)481-484
Number of pages4
JournalJournal of Neurology Neurosurgery and Psychiatry
Volume47
Issue number5
DOIs
Publication statusPublished - 1984
Externally publishedYes

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