Monoclonal antibodies against antigens of the human platelet surface: Preparation and properties

Heddy Zola; P. J. McNamara; I. G.R. Beckman; D. A. Brooks; P. J. Macardle; J. Bradley; K. Goodall; J. Skinner; R. Collins; M. C. Berndt

doi:10.3109/00313028409067914

Monoclonal antibodies against antigens of the human platelet surface: Preparation and properties

Heddy Zola, P. J. McNamara, I. G.R. Beckman, D. A. Brooks, P. J. Macardle, J. Bradley, K. Goodall, J. Skinner, R. Collins, M. C. Berndt

College of Medicine and Public Health

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

Three monoclonal antibodies, FMC24, 25 and 27, reactive with human platelets, are described. In normal blood the 3 antibodies are specific for platelets, but FMC27 reacts with leukemic blast cells in a proportion of acute leukemias. FMC25 precipitates the platelet membrane glycoprotein lb and a glycoprotein of molecular weight 22,000. The antibodies show different effects on platelet aggregation.

Original language	English
Pages (from-to)	73-78
Number of pages	6
Journal	Pathology
Volume	16
Issue number	1
DOIs	https://doi.org/10.3109/00313028409067914
Publication status	Published - Jan 1984

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Acute leukemia
Antibody
Blast cells
Monoclonal
Platelets

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10.3109/00313028409067914Licence: In Copyright

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abstract = "Three monoclonal antibodies, FMC24, 25 and 27, reactive with human platelets, are described. In normal blood the 3 antibodies are specific for platelets, but FMC27 reacts with leukemic blast cells in a proportion of acute leukemias. FMC25 precipitates the platelet membrane glycoprotein lb and a glycoprotein of molecular weight 22,000. The antibodies show different effects on platelet aggregation.",

keywords = "Acute leukemia, Antibody, Blast cells, Monoclonal, Platelets",

author = "Heddy Zola and McNamara, {P. J.} and Beckman, {I. G.R.} and Brooks, {D. A.} and Macardle, {P. J.} and J. Bradley and K. Goodall and J. Skinner and R. Collins and Berndt, {M. C.}",

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T1 - Monoclonal antibodies against antigens of the human platelet surface

T2 - Preparation and properties

AU - Zola, Heddy

AU - McNamara, P. J.

AU - Beckman, I. G.R.

AU - Brooks, D. A.

AU - Macardle, P. J.

AU - Bradley, J.

AU - Goodall, K.

AU - Skinner, J.

AU - Collins, R.

AU - Berndt, M. C.

PY - 1984/1

Y1 - 1984/1

N2 - Three monoclonal antibodies, FMC24, 25 and 27, reactive with human platelets, are described. In normal blood the 3 antibodies are specific for platelets, but FMC27 reacts with leukemic blast cells in a proportion of acute leukemias. FMC25 precipitates the platelet membrane glycoprotein lb and a glycoprotein of molecular weight 22,000. The antibodies show different effects on platelet aggregation.

AB - Three monoclonal antibodies, FMC24, 25 and 27, reactive with human platelets, are described. In normal blood the 3 antibodies are specific for platelets, but FMC27 reacts with leukemic blast cells in a proportion of acute leukemias. FMC25 precipitates the platelet membrane glycoprotein lb and a glycoprotein of molecular weight 22,000. The antibodies show different effects on platelet aggregation.

KW - Acute leukemia

KW - Antibody

KW - Blast cells

KW - Monoclonal

KW - Platelets

UR - http://www.scopus.com/inward/record.url?scp=0021342381&partnerID=8YFLogxK

U2 - 10.3109/00313028409067914

DO - 10.3109/00313028409067914

M3 - Article

C2 - 6232493

AN - SCOPUS:0021342381

SN - 0031-3025

VL - 16

SP - 73

EP - 78

JO - Pathology

JF - Pathology

IS - 1

ER -

Monoclonal antibodies against antigens of the human platelet surface: Preparation and properties

Abstract

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Keywords

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