Morphological Control of Heteroleptic cis- and trans-Pd2L2L′2 Cages

Witold M. Bloch, Julian J. Holstein, Wolf Hiller, Guido H. Clever

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109 Citations (Scopus)
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Control over the integrative self-sorting of metallo-supramolecular assemblies opens up possibilities for introducing increased complexity and function into a single self-assembled architecture. Herein, the relationship between the geometry of three ligand components and morphology of three self-sorted heteroleptic [Pd2L2L′2]4+ cages is examined. Pd-mediated assembly of two bis-monodentate pyridyl ligands with native bite angles of 75° and 120° affords a cis-[Pd2L2L′2]4+ cage while the same reaction with two ligands with bite angles of 75° and 60° gives an unprecedented, self-penetrating structural motif; a trans-[Pd2(anti-L)2L′2]4+ heteroleptic cage with a “doubly bridged figure eight” topology. Each heteroleptic assembly can be formed by cage-to-cage conversion of the homoleptic precursors and morphological control of [Pd2L2L′2] cages is achieved by selective ligand displacement transformations in a system of three ligands and at least six possible cage products.

Original languageEnglish
Pages (from-to)8285-8289
Number of pages5
JournalAngewandte Chemie - International Edition
Issue number28
Early online date23 May 2017
Publication statusPublished - 3 Jul 2017
Externally publishedYes


  • cage compounds
  • morphological control
  • self-sorting
  • supramolecular chemistry
  • topology


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