51 OSA patients were randomised to surgical intervention. Upper airway MRI (T1-weighted) was performed at baseline and 6 months post-surgery. Scans were used to create 3-dimensional volumetric models of the tongue (genioglossus muscle), soft palate, and pharyngeal airway space by manual segmentation. Volume changes were compared by paired t-test, and relationship with AHI change assessed using Spearman's correlation.
Preliminary analysis of 15 subjects has been completed to date (Age: 41.5 ± 11.0 years [mean ± SD]); BMI: 31.9 ± 4.2 kg.m-2; 73.3% male). AHI was confirmed to improve in this subset (baseline:50.7 ± 23/hr, 6-month:17.6 ± 9.0/hr, p < 0.001) with no weight change observed (p = 0.85). No change was observed in MRI volumetric models of the tongue (baseline:97.2 ± 18.2 cm3, 6-month:98.1 ± 17.5 cm3, p = 0.90), soft palate (baseline:9.5 ± 2.3 cm3, 6-month:7.9 ± 1.7 cm3, p = 0.058), or airway space (baseline:19.0 ± 5.9 cm3, 6-month:16.1 ± 4.5 cm3, p = 0.12). Correlation analysis showed no relationship between changes in these volumes and AHI change. Analysis was performed by a single operator, blind to pre- or post-operative status, with good intra-rater reliability (ICC 0.85–0.99, N = 5).
Preliminary analysis did not identify significant changes in 3D MRI modelled pharyngeal volumes 6 months after multilevel upper airway surgery. Work is ongoing to complete volumetric analysis, 3D mandibular dimensions, and measurement of craniofacial structures.
|Number of pages||2|
|Journal||Journal of Sleep Research|
|Publication status||Published - Oct 2019|
|Event||Sleep Down Under 2019: 31st ASM of Australasian Sleep Technologists Association - Sydney, Australia|
Duration: 16 Oct 2019 → 19 Oct 2019
Conference number: 31
- Obstructive sleep apnoea
- Sleep Apnea Multilevel Surgery (SAMS) trial