Multi-step continuous-flow synthesis

Joshua Britton, Colin Raston

    Research output: Contribution to journalReview articlepeer-review

    239 Citations (Scopus)


    Organic chemistry is continually evolving to improve the syntheses of value added and bioactive compounds. Through this progression, a concomitant advancement in laboratory technology has occurred. Many researchers now choose to mediate transformations in continuous-flow systems given the many benefits over round bottom flasks. Furthermore, reaction scale up is often less problematic as this is addressed at the inception of the science. Although single-step transformations in continuous-flow systems are common, multi-step transformations are more valuable. In these systems, molecular complexity is accrued through sequential transformations to a mobile scaffold, much like an in vitro version of Nature's polyketide synthases. Utilizing this methodology, multi-step continuous-flow systems have improved the syntheses of active pharmaceutical ingredients (APIs), natural products, and commodity chemicals. This Review details these advancements while highlighting the rapid progress, benefits, and diversification of this expanding field.

    Original languageEnglish
    Pages (from-to)1250-1271
    Number of pages22
    JournalChemical Society Reviews
    Issue number5
    Early online date20 Jan 2017
    Publication statusPublished - 7 Mar 2017


    • Continuous flow
    • multi-step transformations
    • active pharmaceutical ingredients


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