Multimodal Anti-tumor Approaches Combined with Immunotherapy to Overcome Tumor Resistance in Esophageal and Gastric Cancer

Louisa Bolm, Lukas Kasmann, Annika Paysen, Chris Karapetis, Dirk Rades, Ulrich Wellner, Tobias Keck, David Watson, Richard Hummel, Damian Hussey

    Research output: Contribution to journalArticlepeer-review

    10 Citations (Scopus)

    Abstract

    Upper gastrointestinal malignancies are associated with a high disease burden worldwide, and esophageal and gastric cancers represent the most common entities. Given a lack of early characteristic symptoms and potent screening instruments, the majority of patients present with advanced disease at the time of diagnosis. Complete surgical resection is a first-line curative option, and multimodal approaches involving chemotherapy and radiotherapy further improve patient prognosis. However, response to standard adjuvant and neoadjuvant treatments remains low, and new strategies are warranted to increase tumor control rates. Immunotherapy is emerging in various cancer entities and may be successfully combined with standard therapeutic regimens to improve patient outcome. For the purpose of this review we aimed to assess combined approaches of immunotherapy and standard treatment options such as chemotherapy, radiotherapy and surgery. Current trials evaluating multimodal approaches with immunotherapy in esophageal and gastric cancer are evaluated.

    Original languageEnglish
    Pages (from-to)3231-3242
    Number of pages12
    JournalAnticancer Research
    Volume38
    Issue number6
    DOIs
    Publication statusPublished - 2018

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