Multiple lentigines syndrome (LEOPARD syndrome or progressive cardiomyopathic lentiginosis)

Brian D. Coppin, I. Karen Temple

Research output: Contribution to journalArticlepeer-review

90 Citations (Scopus)


The multiple lentigines syndrome is an autosomal dominant condition which has many similarities to Noonan syndrome, except in the most striking feature from which its name is derived. The less neutral but very apt mnemonic, LEOPARD syndrome, was first used by Gorlin et al to whom the major debt in the definition of this syndrome lies, that is, Lentigines, ECG abnormalities, Ocular hypertelorism/Obstructive cardiomyopathy, Pulmonary valve stenosis, Abnormalities of genitalia in males, Retardation of growth, and Deafness. Not previously included in the mnemonic is cardiomyopathy which is an important feature because it is associated with significant mortality.

Original languageEnglish
Pages (from-to)582-586
Number of pages5
JournalJournal of Medical Genetics
Issue number7
Publication statusPublished - Jul 1997
Externally publishedYes


  • Cardiomyopathy
  • Deafness
  • Lentigines
  • Pulmonary stenosis


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