TY - JOUR
T1 - Multiple sclerosis in Latin America
T2 - A different disease course severity? A collaborative study from the MSBase Registry
AU - Rojas, Juan Ignacio
AU - Patrucco, Liliana
AU - Trojano, Maria
AU - Lugaresi, Alessandra
AU - Izquierdo, Guillermo
AU - Butzkueven, Helmut
AU - Jokubaitis, Vilija
AU - Duquette, Pierre
AU - Girard, Marc
AU - Grand’Maison, Francois
AU - Grammond, Pierre
AU - Oreja-Guevara, Celia
AU - Hupperts, Raymond
AU - Boz, Cavit
AU - Petersen, Thor
AU - Bergamaschi, Roberto
AU - Giuliani, Giorgio
AU - Lechner-Scott, Jeannette
AU - Barnett, Michael
AU - Rio, Maria Edite
AU - Van Pesch, Vincent
AU - Amato, Maria Pia
AU - Iuliano, Gerardo
AU - Fiol, Marcela
AU - Slee, Mark
AU - Verheul, Freek
AU - Fernandez-Bolanos, Ricardo
AU - Poehlau, Dieter
AU - Saladino, Maria Laura
AU - Braber-Moerland, Leontien Den
AU - Deri, Norma
AU - Oleschko-Arruda, Walter
AU - Cabrera-Gomez, Jose Antonio
AU - Paine, Mark
AU - Vella, Norbert
AU - Kister, Ilya
AU - Skromne, Eli
AU - Savino, Aldo
AU - Shaw, Cameron
AU - Moore, Fraser
AU - Vucic, Steve
AU - Petkovska-Boskova, Tatjana
AU - Bacile, Elizabeth Alejandra Bacile
AU - Santiago, Vetere
AU - Cristiano, Edgardo
AU - MSBase Study Group
N1 - Publisher Copyright:
© 2015, © The Author(s) 2015.
PY - 2015/9/1
Y1 - 2015/9/1
N2 - Limited data suggest that multiple sclerosis (MS) in Latin America (LA) could be less severe than in the rest of the world. The objective was to compare the course of MS between LA and other regions. Methods: Centers from 18 countries with >20 cases enrolled in the MSBase Registry participated. Patients with MS with a disease duration of >1 year and <30 years at time of EDSS measurement were evaluated. The MS Severity Score (MSSS) was used as a measure of disease progression. Comparisons among regions (North America, Europe, Australia and LA), hemispheres and countries were performed. Results: A total of 9610 patients were included. Patients were from: Europe, 6290 (65.6%); North America, 1609 (16.7%); Australia, 1119 (11.6%); and LA, 592 (6.1%). The mean MSSS in patients from LA was 4.47 ± 2.8, 4.53 ± 2.8 in North America, 4.51 ± 2.8 in Europe and 4.49 ± 2.7 in Australia. Mean MSSS in the northern hemisphere was 4.51 ± 1.6 compared to 4.48 ± 1.9 in the southern hemisphere. No differences were found for MSSS among hemispheres (p = 0.68), regions (p = 0.96) or countries (p = 0.50). Conclusions: Our analyses did not discover any difference in mean MSSS among patients from different regions, hemispheres or countries.
AB - Limited data suggest that multiple sclerosis (MS) in Latin America (LA) could be less severe than in the rest of the world. The objective was to compare the course of MS between LA and other regions. Methods: Centers from 18 countries with >20 cases enrolled in the MSBase Registry participated. Patients with MS with a disease duration of >1 year and <30 years at time of EDSS measurement were evaluated. The MS Severity Score (MSSS) was used as a measure of disease progression. Comparisons among regions (North America, Europe, Australia and LA), hemispheres and countries were performed. Results: A total of 9610 patients were included. Patients were from: Europe, 6290 (65.6%); North America, 1609 (16.7%); Australia, 1119 (11.6%); and LA, 592 (6.1%). The mean MSSS in patients from LA was 4.47 ± 2.8, 4.53 ± 2.8 in North America, 4.51 ± 2.8 in Europe and 4.49 ± 2.7 in Australia. Mean MSSS in the northern hemisphere was 4.51 ± 1.6 compared to 4.48 ± 1.9 in the southern hemisphere. No differences were found for MSSS among hemispheres (p = 0.68), regions (p = 0.96) or countries (p = 0.50). Conclusions: Our analyses did not discover any difference in mean MSSS among patients from different regions, hemispheres or countries.
KW - disease progression
KW - MSSS
KW - Multiple sclerosis
KW - South America
UR - http://www.scopus.com/inward/record.url?scp=85016241489&partnerID=8YFLogxK
U2 - 10.1177/2055217315600193
DO - 10.1177/2055217315600193
M3 - Article
AN - SCOPUS:85016241489
SN - 2055-2173
VL - 1
SP - 1
EP - 6
JO - Multiple Sclerosis Journal - Experimental, Translational and Clinical
JF - Multiple Sclerosis Journal - Experimental, Translational and Clinical
ER -