Mutation analysis of the Fanconi anaemia A gene in breast tumours with loss of heterozygosity at 16q24.3

A. M. Cleton-Jansen; E. W. Moerland; J. C. Pronk; C. G.M. Van Berkel; S. Apostolou; J. Crawford; A. Savoia; A. D. Auerbach; C. G. Mathew; D. F. Callen; C. J. Cornelisse

doi:10.1038/sj.bjc.6690168

Mutation analysis of the Fanconi anaemia A gene in breast tumours with loss of heterozygosity at 16q24.3

A. M. Cleton-Jansen, E. W. Moerland, J. C. Pronk, C. G.M. Van Berkel, S. Apostolou, J. Crawford, A. Savoia, A. D. Auerbach, C. G. Mathew, D. F. Callen, C. J. Cornelisse

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Abstract

The recently identified Fanconi anaemia A (FAA) gene is located on chromosomal band 16q24.3 within a region that has been frequently reported to show loss of heterozygosity (LOH) in breast cancer. FAA mutation analysis of 19 breast tumours with specific LOH at 16q24.3 was performed. Single-stranded conformational polymorphism (SSCP) analysis on cDNA and genomic DNA, and Southern blotting failed to identify any tumour-specific mutations. Five polymorphisms were identified, but frequencies of occurrence did not deviate from those in a normal control population. Therefore, the FAA gene is not the gene targeted by LOH at 16q24.3 in breast cancer. Another tumour suppressor gene in this chromosomal region remains to be identified.

Original language	English
Pages (from-to)	1049-1052
Number of pages	4
Journal	British Journal of Cancer
Volume	79
Issue number	7-8
DOIs	https://doi.org/10.1038/sj.bjc.6690168
Publication status	Published - 1999
Externally published	Yes

Keywords

Allelic imbalance
Breast cancer
Chromosome 16
Fanconi anaemia
Tumour suppressor gene

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Cleton-Jansen, A. M., Moerland, E. W., Pronk, J. C., Van Berkel, C. G. M., Apostolou, S., Crawford, J., Savoia, A., Auerbach, A. D., Mathew, C. G., Callen, D. F., & Cornelisse, C. J. (1999). Mutation analysis of the Fanconi anaemia A gene in breast tumours with loss of heterozygosity at 16q24.3. British Journal of Cancer, 79(7-8), 1049-1052. https://doi.org/10.1038/sj.bjc.6690168

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title = "Mutation analysis of the Fanconi anaemia A gene in breast tumours with loss of heterozygosity at 16q24.3",

abstract = "The recently identified Fanconi anaemia A (FAA) gene is located on chromosomal band 16q24.3 within a region that has been frequently reported to show loss of heterozygosity (LOH) in breast cancer. FAA mutation analysis of 19 breast tumours with specific LOH at 16q24.3 was performed. Single-stranded conformational polymorphism (SSCP) analysis on cDNA and genomic DNA, and Southern blotting failed to identify any tumour-specific mutations. Five polymorphisms were identified, but frequencies of occurrence did not deviate from those in a normal control population. Therefore, the FAA gene is not the gene targeted by LOH at 16q24.3 in breast cancer. Another tumour suppressor gene in this chromosomal region remains to be identified.",

keywords = "Allelic imbalance, Breast cancer, Chromosome 16, Fanconi anaemia, Tumour suppressor gene",

author = "Cleton-Jansen, {A. M.} and Moerland, {E. W.} and Pronk, {J. C.} and {Van Berkel}, {C. G.M.} and S. Apostolou and J. Crawford and A. Savoia and Auerbach, {A. D.} and Mathew, {C. G.} and Callen, {D. F.} and Cornelisse, {C. J.}",

year = "1999",

doi = "10.1038/sj.bjc.6690168",

language = "English",

volume = "79",

pages = "1049--1052",

journal = "British Journal of Cancer",

issn = "0007-0920",

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TY - JOUR

T1 - Mutation analysis of the Fanconi anaemia A gene in breast tumours with loss of heterozygosity at 16q24.3

AU - Cleton-Jansen, A. M.

AU - Moerland, E. W.

AU - Pronk, J. C.

AU - Van Berkel, C. G.M.

AU - Apostolou, S.

AU - Crawford, J.

AU - Savoia, A.

AU - Auerbach, A. D.

AU - Mathew, C. G.

AU - Callen, D. F.

AU - Cornelisse, C. J.

PY - 1999

Y1 - 1999

N2 - The recently identified Fanconi anaemia A (FAA) gene is located on chromosomal band 16q24.3 within a region that has been frequently reported to show loss of heterozygosity (LOH) in breast cancer. FAA mutation analysis of 19 breast tumours with specific LOH at 16q24.3 was performed. Single-stranded conformational polymorphism (SSCP) analysis on cDNA and genomic DNA, and Southern blotting failed to identify any tumour-specific mutations. Five polymorphisms were identified, but frequencies of occurrence did not deviate from those in a normal control population. Therefore, the FAA gene is not the gene targeted by LOH at 16q24.3 in breast cancer. Another tumour suppressor gene in this chromosomal region remains to be identified.

AB - The recently identified Fanconi anaemia A (FAA) gene is located on chromosomal band 16q24.3 within a region that has been frequently reported to show loss of heterozygosity (LOH) in breast cancer. FAA mutation analysis of 19 breast tumours with specific LOH at 16q24.3 was performed. Single-stranded conformational polymorphism (SSCP) analysis on cDNA and genomic DNA, and Southern blotting failed to identify any tumour-specific mutations. Five polymorphisms were identified, but frequencies of occurrence did not deviate from those in a normal control population. Therefore, the FAA gene is not the gene targeted by LOH at 16q24.3 in breast cancer. Another tumour suppressor gene in this chromosomal region remains to be identified.

KW - Allelic imbalance

KW - Breast cancer

KW - Chromosome 16

KW - Fanconi anaemia

KW - Tumour suppressor gene

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DO - 10.1038/sj.bjc.6690168

M3 - Article

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AN - SCOPUS:0033022427

SN - 0007-0920

VL - 79

SP - 1049

EP - 1052

JO - British Journal of Cancer

JF - British Journal of Cancer

IS - 7-8

ER -

Mutation analysis of the Fanconi anaemia A gene in breast tumours with loss of heterozygosity at 16q24.3

Abstract

Keywords

UN SDGs

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