Mutation frequency in human lymphocytes increases with age

Kevin J. Trainor, Dianne J. Wigmore, Anna Chrysostomou, John L. Dempsey, Ram Seshadri, Alexander A. Morley

Research output: Contribution to journalArticle

118 Citations (Scopus)

Abstract

Several theories of ageing predict that somatic mutations should increase with age. This prediction was tested for human lymphocytes using a recently development clonal technique for enumeration of mutations, and an increase of 1.6% per year in mutations with age was detected.

Original languageEnglish
Pages (from-to)83-86
Number of pages4
JournalMechanisms of Ageing and Development
Volume27
Issue number1
DOIs
Publication statusPublished - Sep 1984
Externally publishedYes

Keywords

  • Age
  • Lymphocytes
  • Somatic mutation

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