Mutation frequency in human lymphocytes increases with age

Kevin J. Trainor, Dianne J. Wigmore, Anna Chrysostomou, John L. Dempsey, Ram Seshadri, Alexander A. Morley

Research output: Contribution to journalArticlepeer-review

124 Citations (Scopus)


Several theories of ageing predict that somatic mutations should increase with age. This prediction was tested for human lymphocytes using a recently development clonal technique for enumeration of mutations, and an increase of 1.6% per year in mutations with age was detected.

Original languageEnglish
Pages (from-to)83-86
Number of pages4
JournalMechanisms of Ageing and Development
Issue number1
Publication statusPublished - Sept 1984
Externally publishedYes


  • Age
  • Lymphocytes
  • Somatic mutation


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