Mutation frequency in human lymphocytes increases with age

Kevin J. Trainor; Dianne J. Wigmore; Anna Chrysostomou; John L. Dempsey; Ram Seshadri; Alexander A. Morley

doi:10.1016/0047-6374(84)90084-8

Mutation frequency in human lymphocytes increases with age

Kevin J. Trainor, Dianne J. Wigmore, Anna Chrysostomou, John L. Dempsey, Ram Seshadri, Alexander A. Morley

Research output: Contribution to journal › Article › peer-review

124 Citations (Scopus)

Abstract

Several theories of ageing predict that somatic mutations should increase with age. This prediction was tested for human lymphocytes using a recently development clonal technique for enumeration of mutations, and an increase of 1.6% per year in mutations with age was detected.

Original language	English
Pages (from-to)	83-86
Number of pages	4
Journal	Mechanisms of Ageing and Development
Volume	27
Issue number	1
DOIs	https://doi.org/10.1016/0047-6374(84)90084-8
Publication status	Published - Sept 1984
Externally published	Yes

Keywords

Age
Lymphocytes
Somatic mutation

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title = "Mutation frequency in human lymphocytes increases with age",

abstract = "Several theories of ageing predict that somatic mutations should increase with age. This prediction was tested for human lymphocytes using a recently development clonal technique for enumeration of mutations, and an increase of 1.6% per year in mutations with age was detected.",

keywords = "Age, Lymphocytes, Somatic mutation",

author = "Trainor, {Kevin J.} and Wigmore, {Dianne J.} and Anna Chrysostomou and Dempsey, {John L.} and Ram Seshadri and Morley, {Alexander A.}",

year = "1984",

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AU - Trainor, Kevin J.

AU - Wigmore, Dianne J.

AU - Chrysostomou, Anna

AU - Dempsey, John L.

AU - Seshadri, Ram

AU - Morley, Alexander A.

PY - 1984/9

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AB - Several theories of ageing predict that somatic mutations should increase with age. This prediction was tested for human lymphocytes using a recently development clonal technique for enumeration of mutations, and an increase of 1.6% per year in mutations with age was detected.

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KW - Lymphocytes

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DO - 10.1016/0047-6374(84)90084-8

M3 - Article

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AN - SCOPUS:0021157587

SN - 0047-6374

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SP - 83

EP - 86

JO - Mechanisms of Ageing and Development

JF - Mechanisms of Ageing and Development

IS - 1

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Mutation frequency in human lymphocytes increases with age

Abstract

Keywords

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